Evidence map›Paper›PMID 42363947›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Serum-based untargeted metabolomics reveals the therapeutic mechanism of asiatic acid against atherosclerosis in ApoE

Zhihao Wu, Luyin Yang, Jie Yang, Zhongji Gou, Hong Yu, Wei Ren

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhihao Wu *Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, China.
Luyin Yang *National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China.
Jie YangSchool of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China.
Zhongji GouDepartment of Neurology, Pengzhou People's Hospital, Pengzhou, 611930, Sichuan, China.
Hong YuSchool of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China. hongyu@swmu.edu.cn.
Wei RenNational Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China. renwei1991@swmu.edu.cn.

Funding

Health Commission of Sichuan Province Medical Science and Technology Program 24QNMP053Science and Technology Strategic Cooperation Project of Pengzhou People's Hospital-Southwest Medical University 2024PZXNYD08The Technology Strategic Cooperation Project of Luzhou Municipal People's Government-Southwest Medical University 2023LZXNYDJ014
6 · The paper itself

Abstract

Atherosclerosis (AS) is a leading cause of cardiovascular morbidity and mortality worldwide. This study investigated the protective effects and underlying mechanisms of asiatic acid (AA), a bioactive triterpenoid from Centella asiatica, in high-fat diet (HFD)-fed ApoE

Indexed as

Anti-Inflammatory AgentsAtherosclerosisPentacyclic TriterpenesAnimalsApolipoproteins EATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolDiet, High-FatLipoproteins, LDLLiverLiver X ReceptorsMaleMetabolomicsMiceMice, Inbred C57BLMice, Knockout, ApoEABCG1 protein, mouseAnti-Inflammatory AgentsApolipoproteins Easiatic acidATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolLipoproteins, LDLLiver X ReceptorsNr1h3 protein, mousePentacyclic TriterpenesPPAR gammaArachidonic acid metabolismAsiatic acidAtherosclerosisUntargeted metabolomics

Identifiers

PMID42363947

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.