ArticleThe Eurasian journal of medicine2026
Plasma Atherogenic Index Predicts Malignant Arrhythmias in Non-STElevation Myocardial Infarction.
Article in The Eurasian journal of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMalignant ventricular arrhythmias are serious complications of non-ST-elevation myocardial infarction. The plasma atherogenic index, derived from triglyceride and high-density lipoprotein cholesterol, reflects atherogenic dyslipidemia. Its role in predicting malignant arrhythmias is unclear. The primary aim of this study was to determine whether the plasma atherogenic index independently predicts malignant ventricular arrhythmias in patients with non-ST-elevation myocardial infarction.
methodsA total of 502 patients with non-ST-elevation myocardial infarction admitted between January 2024 and January 2025 were retrospectively analyzed. Patients were grouped by arrhythmia occurrence and tertiles of the plasma atherogenic index. Logistic regression identified predictors of arrhythmias. Cox regression identified predictors of malignant arrhythmias. Receiver operating characteristic analysis assessed discriminative performance, and Kaplan-Meier analysis evaluated survival.
resultsMalignant ventricular arrhythmias occurred in 47 patients (9.4%). They had significantly higher plasma atherogenic index values (0.48 Å} 0.35 vs. 0.21 Å} 0.29, P < .001). In multivariable analysis, multivessel disease, neutrophil, troponin T, low-density lipoprotein cholesterol, reduced ejection fraction, and the plasma atherogenic index independently predicted arrhythmias. For mortality, no-reflow, troponin T, malignant arrhythmia, and the plasma atherogenic index (hazard ratio 1.342, 95% confidence interval 1.211-1.487, P = .006) were independent predictors. The plasma atherogenic index had the highest discriminative value (area under the curve 0.721 for arrhythmias; 0.709 for mortality) with a cut-off of 0.32 (sensitivity 68%, specificity 68%). Kaplan-Meier analysis showed lower survival in the highest tertile.
conclusionElevated plasma atherogenic index independently predicts malignant arrhythmias and shortterm mortality in non-ST-elevation myocardial infarction. As a simple, widely available lipid marker, it may improve risk stratification in high-risk patients. Cite this article as: Taş A, Ateş MS, Tunca .. Plasma atherogenic index predicts malignant arrhythmias in non-ST-elevation myocardial infarction. Eurasian J Med. 2026, 58(3), 1315, doi: 10.5152/eurasianjmed.2026.251315.
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