Evidence map›Paper›PMID 42364413›Full record

ArticleInternational dental journal2026

Decoding the Dynamic Landscape of Sequential Disease Stages from Oral Submucous Fibrosis to Oral Squamous Cell Carcinoma.

Xin Bin, Jingyi Cheng, Jianjun Wu, Zhangui Tang, Yufei Sun, Kaixin Su, Kun Li, Yanjian Hu, Hongzhi Quan, Zhiyuan Deng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xin BinXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Jingyi ChengXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Jianjun WuXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Zhangui TangXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Yufei SunDepartment of General Surgery, Xiangya Hospital, Central South University, Hunan, China.
Kaixin SuXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Kun LiXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Yanjian HuXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Hongzhi QuanXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Zhiyuan DengXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Baisheng WangXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China.
Qian TangXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China. Electronic address: llqian1992@163.com.
Ousheng LiuXiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Academician Workstation for Oral-maxilofacial and Regenerative Medicine, Central South University, Changsha, Hunan, China. Electronic address: liuousheng@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral submucous fibrosis (OSF) is a chronic and progressive disease of the oral mucosa that is considered potentially malignant. However, the specific mechanism of OSF occurrence and malignant transformation into oral squamous cell carcinoma (OSCC) is still unclear. This study aimed to elucidate the spatiotemporal changes in cellular biological behaviour during the occurrence and malignant transformation of OSF, providing new insights for understanding the underlying mechanism and developing novel therapeutic strategies. Sets of normal, OSF, margin area, and OSCC tissue samples were collected, and 10 × Visium spatial transcriptomics technology was used for sequencing library construction. The spatial transcriptomic data were combined with single-cell transcriptomic data for analysis. Phenotypic shifts in fibroblasts drove the progression of diverse disease stages, and immune cell patterns revealed adaptive immune dominance in OSF and immunosuppression in OSCC. A distinctive transitional zone with low transcriptional activity and intermediate transcriptomic features between noncancerous and cancer cells was identified at the forefront of the cancer invasion margin. Moreover, cancer-side cells had increased cell-cell communication around the tumour margin, reprogramming the adjacent microenvironment to facilitate invasion. The differential end states of epithelial cells demonstrated that basal epithelial cells were the dominant cell source of cancer cells in OSCC. Dynamic changes occur in gene expression and cellular function during the transformation of OSF into OSCC. The malignant transformation of OSF is a complex process involving multiple cell populations, in which changes first occur in cellular biological behaviours instead of pathomorphology. These spatiotemporal insights provide important evidence for clarifying the mechanisms of OSF-OSCC transformation and offer potential targets for early intervention. The identified transitional zone presents potential targets for early intervention in OSF patients at high risk of malignant transformation, supporting the development of strategies for OSCC prevention and precise clinical management.

Indexed as

Cancer invasionMalignant transformationOral squamous cell carcinomaOral submucous fibrosisSpatial transcriptomics

Identifiers

PMID42364413
PMCPMC13324440

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.