Evidence mapPaperPMID 42365112Full record

ReviewArchives of toxicology2026

Copper oxide nanoparticles: from EU-regulatory landscape and mechanistic toxicity towards a cuproptosis-linked adverse outcome pathway.

Sophie Scholz, Julia Prinz, Linde Sevenants, Andrea Holzwarth, Birgit Mertens, Robert Pieper, Vera Ritz, Kirsten Schulz, Holger Sieg, Aswin Mangerich and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sophie ScholzGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.ORCID http://orcid.org/0000-0003-3375-993X
Julia PrinzGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Linde SevenantsSciensano (Belgian Institute for Health), J. Wytsmanstraat 14, 1050, Brussels, Belgium.ORCID http://orcid.org/0009-0005-1681-2251
Andrea HolzwarthGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.
Birgit MertensSciensano (Belgian Institute for Health), J. Wytsmanstraat 14, 1050, Brussels, Belgium.ORCID http://orcid.org/0000-0001-8298-9104
Robert PieperGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.ORCID http://orcid.org/0000-0002-0292-1482
Vera RitzGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.ORCID http://orcid.org/0000-0002-7360-3107
Kirsten SchulzGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.ORCID http://orcid.org/0000-0002-0090-761X
Holger SiegGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Holger.Sieg@bfr.bund.de.ORCID http://orcid.org/0000-0002-0593-0173
Aswin MangerichInstitute of Nutritional Science, Nutritional Toxicology Group, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany. Mangerich@uni-potsdam.de.ORCID http://orcid.org/0000-0001-9742-2338
Linda BöhmertGerman Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Linda.Boehmert@bfr.bund.de.ORCID http://orcid.org/0000-0002-1153-2841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace element, yet concerns regarding its toxic potential have gained increasing attention, particularly with regard to nanoparticulate forms of copper oxides. Both CuO and Cu

Indexed as

AOPCopper oxidesCuproptosisNanotoxicologyUptake mechanism

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.