Evidence map›Paper›PMID 42365161›Full record

ArticleScientific reports2026

Sex-specific mitochondrial dysregulation and metformin response in Wilson disease.

Valentina Medici, Noreene Shibata, Aldo Vorkapich, Jennifer Dang, Rida Mullah, Atena Tork, Isabel F Snodgrass, Dohee Kim, John W Newman, Zoe Lee Greenblatt and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Valentina MediciDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, CA, USA.
Noreene ShibataDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, CA, USA.
Aldo VorkapichDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Jennifer DangDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Rida MullahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Atena TorkDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Isabel F SnodgrassWest Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA, USA.
Dohee KimUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, USA.
John W NewmanUnited States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA, USA.
Zoe Lee GreenblattDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Huy-An TranDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Ieleen LiDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Keren SierraDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Qixuan GongDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Cecilia GiuliviDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA. cgiulivi@ucdavis.edu.ORCID https://orcid.org/0000-0003-1033-7435

Funding

Bridges to the BaccalaureateT34GM150440 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Marina Lyn Ellefson Crowder, Marc Tancredi Facciotti · 2023 to 2026
$1.1M
NIGMS NIH HHS T34 GM150440NIH HHS 5T34GM150440-02USDA Rural Development 20232-51530-025-00D
6 · The paper itself

Abstract

Wilson disease (WD) is an inherited disorder of copper metabolism characterized by hepatic copper accumulation, mitochondrial injury, and systemic metabolic dysfunction. Metformin is a widely used antihyperglycemic agent with known effects on mitochondrial metabolism and cellular redox state. We tested whether metformin modifies hepatic mitochondrial abnormalities in a mouse model of WD, stratified by sex. Adult male and female Atp7b

Indexed as

Chelating agentsCopper toxicosisGlucocorticoidsLipidomicsLiverMitochondrial ultrastructureOxidative stress

Identifiers

PMID42365161
PMCPMC13597304

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.