ArticlePediatric research2026
Aortic elastic properties and circulating matrix biomarkers in children with bicuspid aortic valve: an exploratory study.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bicuspid Aortic Valve Disease-Associated Aortopathy in Pediatric Subjects-From Traditional Assessment to Current Advances and Future Perspectives: A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Circulating Extracellular Matrix-Remodeling Biomarkers in Children with Bicuspid Aortic Valve: An Exploratory Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBicuspid aortic valve (BAV) is associated with early aortopathy that may precede overt aortic dilatation. Functional assessment of aortic biomechanics and extracellular matrix (ECM) biomarkers may provide additional insight beyond conventional diameter-based evaluation.
methodsIn this prospective case-control study, 40 children with BAV and 40 healthy controls underwent echocardiographic assessment of ascending aortic elastic properties and left ventricular global longitudinal strain (GLS). ECM-related biomarkers were measured using ELISA.
resultsChildren with BAV demonstrated significantly impaired aortic elastic properties, including lower aortic strain (14.79 ± 2.41 vs 21.03 ± 2.94) and distensibility (2.3 [2.0-3.15] vs 4.7 [4.1-5.7] ×10⁻³ mmHg⁻¹, p < 0.001) and higher aortic stiffness index despite preserved GLS (p > 0.05). Ascending aortic Z-scores were significantly higher in the BAV group. Serum MMP-2, MMP-9, and MMP-2/TIMP-1 ratio levels were elevated in children with BAV and were associated with impaired aortic elastic parameters. TGF-β1 levels did not differ between groups but demonstrated modest correlations with aortic biomechanics within the BAV cohort.
conclusionIn children with BAV, impaired aortic biomechanics and ECM remodeling appear to precede before overt myocardial dysfunction. Integrated functional imaging and biomarker assessment may enhance detection of BAV-related aortopathy. IMPACT: Functional impairment of aortic biomechanics and extracellular matrix remodeling are detectable in children with bicuspid aortic valve before overt aortic dilatation or myocardial dysfunction. This study integrates aortic strain-based functional imaging with circulating ECM biomarkers, providing pediatric evidence that biomechanical deterioration precedes structural aortopathy. Early functional aortic assessment may improve risk stratification and longitudinal surveillance strategies in pediatric patients with bicuspid aortic valve.
Identifiers
42365165What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.