ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Effect of "Tongdu Yupi Tiaoshen" electroacupuncture on behavioral performance and hippocampal structure and function in chronic fatigue syndrome rats.
Q U Yuanyuan, Feng Chuwen, Sun Weibo, Shao Yuying, L U Jing, Guo Shuhao, L I Binbin, Yang Tiansong
Abstract read
In one paragraphArticle in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Q U YuanyuanRehabilitation Department Ⅱ, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Feng ChuwenRehabilitation Department Ⅱ, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Sun WeiboDepartment of Breast Surgery, Harbin Medical University Affiliated Cancer Hospital, Harbin 150076, China.
Shao YuyingRehabilitation Department Ⅱ, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
L U JingGraduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Guo ShuhaoGraduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
L I BinbinRehabilitation Department Ⅱ, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Yang TiansongRehabilitation Department Ⅱ, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Funding
China Association of Chinese Medicine: Chinese Medicine Young Talent Support Project CACM-2023-QNRC2-A04Heilongjiang Province Postdoctoral Research Funding Program: Mechanism of Electroacupuncture Regulating p-T19 Postsynaptic Density protein-95 and Modulating Mitophagy in Synaptic Reconstruction to Improve Cognitive Impairment in Chronic Fatigue Syndrome Rats LBH-Z24291Heilongjiang Provincial Association of Chinese Medicine Young Talent Support Project (2022-2024): Mechanism of the "Tongdu Yupi Tiaoshen" Acupuncture Technique in Improving Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Cognitive Dysfunction 2022-QNRC1-05Heilongjiang Provincial Key Research and Development Program Project (Directed Commission): Development of a Central-peripheral closed-loop Regulation Rehabilitation Robot for Post-stroke Cognitive Impairment Based on Traditional Chinese Medicine Acupuncture Theory 2024ZXDXC50Heilongjiang Provincial Traditional Chinese Medicine Research Project: Mechanism of Electroacupuncture in Regulating Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Rats with Cognitive Dysfunction ZHY2022-136Ministry of Education "Chunhui Program" Collaborative Research Project: Mechanism of the "Tongdu Yupi Tiaoshen" Acupuncture Technique in Improving Hippocampal Synaptic Plasticity in Chronic Fatigue Syndrome Cognitive Dysfunction HZKY20220308-202201357National Natural Science Foundation Cultivation Support Program (Young Scientists) of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine: Mechanism of Electroacupuncture Intervention in the Butyrate Gut-brain Axis Affecting p-T19 Postsynaptic Density Protein-95 to Promote Autophagy and Improve Cognitive Impairment in Chronic Fatigue Syndrome Rats PYQN202501002National Natural Science Foundation of China (General Program): Mechanism of Electroacupuncture Regulating Mouse Double Minute 2 Ubiquitination of Postsynaptic Density protein-95 to Remodel Hippocampal Synaptic Structure and Improve Cognitive Dysfunction in Chronic Fatigue Syndrome 82074539National Natural Science Foundation of China (Young Scientists Program): Mechanism of Moxibustion Activating Calcium-calmodulin-dependent Protein Kinase II Phosphorylation-mediated Long-term Potentiation to Regulate Synaptic Plasticity in Treating Chronic Fatigue Syndrome Cognitive Impairment 82305394National Natural Science Foundation of China (Young Scientists Program): Role and Mechanism of Nuclear Factor Kappa B in Electroacupuncture Against Chronic Fatigue Syndrome Based on the Transforming Growth Factor-beta/Smad Signaling Pathway 81704170Natural Science Foundation of Heilongjiang Province (General Program): Mechanism of Electroacupuncture Regulating Mitochondrial Dynamics to Promote Synaptic Remodeling in Chronic Fatigue Syndrome Rats with Cognitive Impairment LH2024H050
6 · The paper itselfAbstract
objectiveTo investigate the effects of electroacupuncture intervention on behavioral performance, hippocampal structure, and function in chronic fatigue syndrome (CFS) rats and to explore the underlying mechanisms.
methodsSpecific pathogen free-grade male Sprague-Dawley rats were randomly allocated into a control group (Con group,
resultsBehavioral assessments demonstrated that electroacupuncture intervention significantly improved rat performance as measured by GSQS, MWMT, OFT, and Exhaustive Treadmill Test. Both HE and Nissl staining results confirmed that, compared with the blank control group, the model group exhibited abnormal cellular morphology, disorganized arrangement, and reduced Nissl bodies in the hippocampal CA1 region. These pathological alterations were ameliorated in the electroacupuncture group relative to the model group. 18F-FDG PET/CT imaging revealed that following treatment, the mean and maximum standardized uptake values (SUV) in the anterior-dorsal and posterior hippocampus were significantly decreased in the Mod group compared to the Con group. In contrast, electroacupuncture treatment significantly increased both SUV-mean and SUV-max in these hippocampal subregions in the EA group relative to the Mod group (all
conclusionElectroacupuncture intervention alleviated cognitive impairment, hippocampal pathological structural changes, and glucose metabolism dysfunction in a rat model of chronic fatigue syndrome induced by an improved chronic multi-factor compound stress stimulation method.
Indexed as
ElectroacupunctureFatigue Syndrome, ChronicHippocampusAcupuncture PointsAnimalsBehavior, AnimalHumansMaleRatsRats, Sprague-Dawleychronic fatigue syndromecognitive dysfunctionelectroacupuncturehippocampal functionshippocampal structures
Identifiers
PMID42365408
PMCPMC13266329
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