Evidence map›Paper›PMID 42365411›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Network pharmacology and experimental validation of asiaticoside protecting against diabetic kidney disease by regulating 11β-hydroxysteroid dehydrogenase type 2.

Zhu Qin, B I Peng, Zeng Jiali, Zhang Yang, H U Lidan, Cao Zhongkai, Zhu Jingyu, Jin Qinyang

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zhu QinDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
B I PengDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
Zeng JialiDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
Zhang YangDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
H U Lidanthe Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Cao Zhongkaithe Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Zhu JingyuDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
Jin QinyangGeriatric Medicine Center, Department of Geriatric Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China.

Funding

Hangzhou Science and Technology Bureau project: Precise Diagnosis of Prostate Malignancies Using Artificial Intelligence 20231203A12Medical Scientific Research Foundation of Zhejiang Province, China: Mechanistic Study of Asiaticoside in Regulating Macrophage Innate Immune Response in Diabetic Kidney Disease by Maintaining Cholesterol Homeostasis via the DHCR24/Desmosterol/ LXR Signaling Axis 2023RC242National Natural Science Foundation of China for Young Scholars: Study on the Mechanism of Compound Centella Asiatica Mediate 24-dehydrocholesterol Reductase (DHCR24)/Liver X Receptor (LXR) Signaling Axis to Regulate Macrophage Activation and Alleviate Microinflammation in Diabetic Kidney Disease 82205008Special key research project of the Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine: Study on Clinical Auxiliary Decision-Making Model for Professor Wang Yongjun in Diagnosis and Treatment of Diabetic Kidney Disease Based on Graph Convolutional Neural Network 2022FSYYZZ14Zhejiang Traditional Medicine and Technology Program, China: Research on the Construction of a Knowledge Graph for the Academic Thoughts and Clinical Experience of Famous Traditional Chinese Medicine Practitioner Chen Hongyu in Diagnosing and Treating Diabetic Kidney Disease 2023ZF137
6 · The paper itself

Abstract

objectiveTo explore the protective effects and mechanisms of Asiaticoside (AC) against diabetic kidney disease (DKD) through network pharmacology combined with

methodsBased on network pharmacology and RNA sequencing (RNA-Seq) analyses, combined with molecular docking, the core targets and signaling pathways of AC in the treatment of DKD were predicted and screened. Subsequently, the therapeutic effect of AC on DKD was validated in db/db mice and SV40-MES-13 cells, and its molecular mechanism was evaluated.

resultsNetwork pharmacology and protein-protein interaction analyses identified 11-beta hydroxysteroid dehydrogenase type 2 (

conclusionAC may alleviate DKD-related pathological processes by regulating

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 2Diabetic NephropathiesProtective AgentsTriterpenesAnimalsHumansMaleMiceMice, Inbred C57BLMolecular Docking SimulationNetwork PharmacologySignal Transduction11-beta-Hydroxysteroid Dehydrogenase Type 2asiaticosideProtective AgentsTriterpenesasiaticosidediabetic kidney diseasehydroxysteroid 11-beta dehydrogenase 2molecular dockingnetwork pharmacologyRNA-sequencing

Identifiers

PMID42365411
PMCPMC13266319

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.