Evidence map›Paper›PMID 42365412›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

A multicenter randomized controlled trial and metabolomics exploration of Traditional Chinese Medicine pattern-based therapy for stable chronic obstructive pulmonary disease.

Ding Huanzhang, Wang Hui, Yang Qinjun, M A Xiao, W U Di, L I Qiao, Zheng Caixia, L U Jiasheng, W U Chengming, Huang Pingfu and 9 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Ding HuanzhangDepartment of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China.
Wang HuiCollege of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230000, China.
Yang QinjunCollege of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230000, China.
M A XiaoCollege of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230000, China.
W U DiDepartment of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China.
L I QiaoDepartment of Respiratory Medicine, Jieshou Hospital of Traditional Chinese Medicine, Jieshou 236500, China.
Zheng CaixiaDepartment of Respiratory Medicine, Huaibei Hospital of Traditional Chinese Medicine, Huaibei 235000, China.
L U JiashengDepartment of Respiratory Medicine, Taihe Hospital of Traditional Chinese Medicine, Taihe 236600, China.
W U ChengmingDepartment of Respiratory Medicine, Bozhou Hospital of Traditional Chinese Medicine, Bozhou 236000, China.
Huang PingfuDepartment of Respiratory Medicine, Chuzhou Integrated Traditional Chinese and Western Medicine Hospital, Chuzhou 239000, China.
Chen ZhixiangDepartment of Respiratory Medicine, Wuhu Hospital of Traditional Chinese Medicine, Wuhu 241000, China.
Wang ShihanDepartment of Respiratory Medicine, Lu'an Hospital of Traditional Chinese Medicine, Lu'an 237000, China.
Feng JihongDepartment of Respiratory Medicine, Second Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin 300250, China.
Liu JianDepartment of Respiratory Medicine, Second Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin 300250, China.
Sun DengdiSchool of Computer Science and Technology, Anhui University, Hefei 230601, China.
Zhu JieCollege of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230000, China.
Tong JiabingDepartment of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China.
Gao YatingDepartment of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China.
L I ZegengDepartment of Respiratory Medicine, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China.

Funding

National Natural Science Foundation of China-funded Project: Discussion of Molecular Mechanisms of Xin'an Guben Peiyuan Method Based on Inflammation Immune Network Regulation to Improve Chronic Obstructive Pulmonary Disease Patient Perception Through Formula Syndrome Correspondence U20A20398Natural Science Foundation of Anhui Province-funded Project: Experimental Study on Regulation of Immune Function in Chronic Obstructive Pulmonary Disease Rats with Phlegm Stasis Obstructing Lung Syndrome by Yiqi Huatan Quyu Formula Through Lung Gut Microbiota Imbalance 2208085QH264
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of Traditional Chinese Medicine (TCM) pattern-based comprehensive therapy on stable chronic obstructive pulmonary disease (COPD) patients and its influence on metabolic profiles.

methodsIn this multicenter trial, 270 participants from nine hospitals were randomly divided into a trial group and a control group at a 1∶2 ratio. The trial group received Tiotropium Bromide Powder for Inhalation (TBPI) plus one of three TCM granules [Shenqi Wenfei formula, Shenqi Buzhong formula, or Shenqi Tiaoshen formula], while the control group got only TBPI. The study had a 24-week treatment and 52-week follow-up. The main outcome was the frequency of acute COPD exacerbations. Secondary outcomes included related rates, scores on COPD assessment test (CAT) and modified medical research council (mMRC) dyspnea scale, 6-min walk test (6MWT) distance, and lung function, measured at weeks 0, 24, and 52. Serum samples for metabolomics were taken from the trial group before/after treatment and from healthy people.

resultsA total of 256 out of 270 patients completed the study. The trial group had fewer acute exacerbations than the control group during 52-week follow-up (

conclusionTCM pattern-based comprehensive therapy reduces acute exacerbation risk and improves quality of life, respiratory symptoms, and exercise tolerance in stable COPD patients, likely by modulating energy, protein, and amino acid metabolism pathways.

Indexed as

Drugs, Chinese HerbalPulmonary Disease, Chronic ObstructiveAgedFemaleHumansMaleMedicine, Chinese TraditionalMetabolomicsMiddle AgedTreatment OutcomeDrugs, Chinese Herbalmetabolomicspulmonary disease, chronic obstructiveShenqi Buzhong formulaShenqi Tiaoshen formulaShenqi Wenfei formulaTraditional Chinese Medicine pattern

Identifiers

PMID42365412
PMCPMC13266332

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.