Evidence map›Paper›PMID 42365822›Full record

ArticleRedox biology2026

Sulfhydrated TFEB alleviates blast-induced lung injury by maintaining epithelial barrier integrity through the IGF2R/MMP-2/9 pathway.

Jian-Kui Du, Cheng-Jian Luo, Jun-Hui Zhan, An-Xin Xiang, You-Yi Zhang, Peng Wang, Wei-Na Liu, Miao Wang, Wen-Qing Bao, Cheng-Yu Liu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jian-Kui DuDepartment of Physiology, Naval Medical University, Shanghai, China.
Cheng-Jian LuoDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jun-Hui ZhanDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
An-Xin XiangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
You-Yi ZhangDepartment of Gynecology and Obstetrics, General Hospital of Western Theater Command of PLA, Chengdu, China.
Peng WangCollege of Physical Education, Anqing Normal University, Anqing, Anhui, China.
Wei-Na LiuDepartment of Pediatrics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Miao WangDaytime Surgery Ward, Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Wen-Qing BaoDepartment of Oncology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Cheng-Yu LiuDepartment of Physiology, Naval Medical University, Shanghai, China.
Sen-Yuan KangDepartment of Physiology, Naval Medical University, Shanghai, China.
Bo-Wen JiaDepartment of Physiology, Naval Medical University, Shanghai, China.
Jing-Yu WangDepartment of Physiology, Naval Medical University, Shanghai, China.
Jia-Ju ZouDepartment of Physiology, Naval Medical University, Shanghai, China.
Ou-Ou GaoDepartment of Physiology, Naval Medical University, Shanghai, China.
Lei ZhangThe First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Liang ChenLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai, China. Electronic address: xiaoj@smmu.edu.cn.
Chang-Nan WangLab of Stress Injury, School of Life Sciences, Shanghai University, Shanghai, China. Electronic address: wangchangnan@shu.edu.cn.
Jian XiaoDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China. Electronic address: liangchenbio@shu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blast-induced lung injury (BLI) is a life-threatening complication of explosive shock waves, yet its molecular mechanisms remain largely unclear. This study aimed to elucidate the key molecular mechanisms governing epithelial barrier integrity during BLI progression and define the core regulatory function of Transcription Factor EB (TFEB) and its downstream signaling axis in BLI pathogenesis. We also evaluated the therapeutic effect and underlying mechanism of the hydrogen sulfide (H

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsBlast InjuriesLung InjuryMatrix Metalloproteinase 2Matrix Metalloproteinase 9Receptor, IGF Type 2AnimalsDisease Models, AnimalEpithelial CellsHumansHydrogen SulfideMiceSignal TransductionBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsHydrogen SulfideMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, mouseReceptor, IGF Type 2Tcfeb protein, mouseAutophagyBlast lung injuryPt@Pd–SS-sulfhydrationTFEB

Identifiers

PMID42365822
PMCPMC13321394

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.