Evidence map›Paper›PMID 42365859›Full record

ArticleObesity (Silver Spring, Md.)2026

DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.

Riorden O'Shea, Jennie Hui, Chrianna Bharat, Kevin Murray, Gillian Arscott, Michael Hunter, John Walsh, Kun Zhu

Abstract read
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In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Riorden O'SheaWA Country Health Service, Perth, Western Australia, Australia.ORCID https://orcid.org/0009-0006-1460-9847
Jennie HuiSchool of Population and Global Health, University of Western Australia, Perth, Australia.ORCID https://orcid.org/0000-0002-1653-2496
Chrianna BharatSchool of Population and Global Health, University of Western Australia, Perth, Australia.
Kevin MurraySchool of Population and Global Health, University of Western Australia, Perth, Australia.
Gillian ArscottDepartment of Diagnostic Genomics, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australia.
Michael HunterSchool of Population and Global Health, University of Western Australia, Perth, Australia.
John WalshMedical School, The University of Western Australia, Perth, Australia.
Kun ZhuMedical School, The University of Western Australia, Perth, Australia.

Funding

Busselton Population Medical Research InstituteCharlies Foundation for ResearchCity of BusseltonDepartment of Health, Government of Western AustraliaDepartment of Jobs, Tourism, Science and Innovation, Government of Western AustraliaFederal Government of AustraliaNational Health and Medical Research Council
6 · The paper itself

Abstract

objectiveObesity, particularly excess visceral adipose tissue (VAT), may accelerate biological aging; however, few studies have examined this in middle-aged adults. We investigated associations between dual-energy X-ray absorptiometry (DXA)-derived VAT and two biomarkers of biological aging-phenotypic age acceleration (PhenoAgeAccel) and leukocyte telomere length (LTL)-in 4799 participants (2614 females, aged 45-69 years) from the Busselton Healthy Ageing Study.

methodsWhole-body DXA (GE Lunar) quantified VAT mass. Phenotypic age was estimated from chronological age and nine biomarkers. In a subsample of 1221 participants, LTL was measured as the telomeric DNA to single-copy gene (T/S) ratio. Sex-stratified linear regressions assessed associations, adjusting for chronological age and lifestyle factors.

resultsMean ± SD VAT mass was 1677 ± 873 g in males and 882 ± 598 g in females. Higher VAT was associated with greater PhenoAgeAccel in both sexes; each 1-SD increase in VAT corresponds to 1.397 (95% CI 1.197, 1.596) and 1.919 (1.738, 2.099) years higher PhenoAgeAccel in males and females, respectively. In females only, higher VAT was associated with shorter LTL (-0.041 [-0.069, -0.013] per 1 SD). Associations mostly remained significant after adjustment for anthropometric and other DXA-derived adiposity measures.

conclusionsVAT may represent a specific marker of accelerated biological aging, independent of lifestyle and adiposity measures.

Indexed as

Absorptiometry, PhotonAgingIntra-Abdominal FatObesityAdiposityAgedBiomarkersFemaleHumansLeukocytesMaleMiddle AgedTelomereBiomarkersbiological agingdual‐energy X‐ray absorptiometryleukocyte telomere lengthphenotypic age accelerationvisceral adipose tissue

Identifiers

PMID42365859
PMCPMC13422660

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.