Evidence map›Paper›PMID 42366180›Full record

ReviewDiabetes, obesity & metabolism2026

The Ageing Adipose Paradox: Implications for Metabolic Health.

Dana Bou Matar, Muhammad Affan Elahi, Walid Khaled Nassar, Mohammed I Alotaibi, David Murphy, Hana M A Fakhoury, Ahmad Aljada

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dana Bou MatarDepartment of Physiology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Muhammad Affan ElahiCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Walid Khaled NassarCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0007-2148-0006
Mohammed I AlotaibiBristol Medical School: Translational Health Sciences, University of Bristol, Dorothy Hodgkin Building, Bristol, UK.
David MurphyCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Hana M A FakhouryBristol Medical School: Translational Health Sciences, University of Bristol, Dorothy Hodgkin Building, Bristol, UK.
Ahmad AljadaBristol Medical School: Translational Health Sciences, University of Bristol, Dorothy Hodgkin Building, Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreadipocyte commitment to the adipogenic lineage declines markedly with advancing age, while triglyceride accumulation in hypertrophied existing adipocytes persists or expands. This creates a dissociation between adipogenic capacity and lipid-buffering demand, progressively weakening depot metabolic competence and contributing to systemic insulin resistance.

objectiveThis review examines the molecular mechanisms linking impaired adipose tissue plasticity during ageing to metabolic decline, and appraises therapeutic strategies that may restore adipose progenitor competence or limit downstream metabolic dysfunction. KEY

findingsAgeing adipose tissue is characterized by four interlocking defects. First, transcriptional reprogramming, including induction of the inhibitory CCAAT/enhancer-binding protein β-LIP isoform through CUG triplet repeat-binding protein 1, together with reduced C/EBPα and peroxisome proliferator-activated receptor γ activity, shifts progenitors away from differentiation and toward hypertrophic lipid storage. Second, SIRT7 opposes SIRT1 in regulating adipogenic commitment, implicating sirtuin and NAD THERAPEUTIC IMPLICATIONS: Senolytics, NAD

conclusionRestoring adipose progenitor competence while preserving depot-specific metabolic identity may help slow age-related metabolic deterioration and prolong healthspan.

Indexed as

Adipose TissueAgingAdipocytesAdipogenesisAnimalsHumansInsulin Resistanceadipogenesisadipose tissueageinglaminsmetabolic riskSASPsenescencesirtuins

Identifiers

PMID42366180
PMCPMC13449016

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.