Evidence map›Paper›PMID 42366741›Full record

ArticleTransboundary and emerging diseases2026

Celastrol Suppresses Porcine Deltacoronavirus Replication by Modulating Endoplasmic Reticulum Stress-Associated Ca

Jialu Zhang, Yuqian Liu, Letao Gao, Wenzhe Liu, Ru Yan, Die Zhu, Zhouyuan Wang, Lianci Peng, Rendong Fang, Tingting Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jialu ZhangJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0000-0001-7237-5942
Yuqian LiuJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Letao GaoJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Wenzhe LiuJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Ru YanJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Die ZhuJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Zhouyuan WangKunming Hemeihua Feed Limited Company, Kunming, 682100, Yunnan Province, China.
Lianci PengJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.
Rendong FangJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0000-0003-3094-5059
Tingting ChenJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, 400715, China, swu.edu.cn.ORCID https://orcid.org/0009-0005-8224-5232

Funding

Co-construction Project of Fuling Academy of Southwest University FLYJY202506Fundamental Research Funds for the Central Universities SWU-KQ25021Modern Agricultural Industry Technology System CQMAITS202512National Natural Science Foundation of China 32473027National Natural Science Foundation of China 32503119Natural Science Foundation of Chongqing Municipality CSTB2025NSCQ-GPX0489Yunnan Province Science and Technology Talents and Platform Program 202405AF140106
6 · The paper itself

Abstract

Porcine deltacoronavirus (PDCoV) infection causes watery diarrhea and even death in neonatal piglets, leading to substantial economic losses. Meanwhile, emerging evidence indicates the potential risk of PDCoV to threaten human health and public safety. However, the effective vaccines or medicines are deficient. In this study, we evaluated the anti-PDCoV effect of celastrol (CE), a bioactive compound extracted from Tripterygium wilfordii. The results showed that CE significantly inhibited PDCoV replication in a dose-dependent manner and targeted multiple lifecycle stages of the virus. Network pharmacology analysis suggested a potential involvement of endoplasmic reticulum (ER)-related pathways in the antiviral mechanism of CE. Further investigation demonstrated that PDCoV infection induced calcium accumulation, which was restored to the baseline by the treatment of CE. Modulation of cellular calcium using chelating or supplementation approaches also influenced PDCoV replication, indicating an association between calcium homeostasis and viral infection. In addition, PDCoV also induced ER stress and increased the calcium level associated with ER, which was attenuated by CE administration. Pharmacological inhibition of ER stress similarly reduced viral replication and altered calcium distribution. Moreover, the molecular docking analysis further suggested that CE may interact with multiple viral proteins, indicating a potential multitarget antiviral profile. Taken together, these findings demonstrate that CE inhibits PDCoV replication in LLC-PK1 cells and is correlated with the regulation of ER stress-associated calcium homeostasis, providing mechanistic insights into host-virus interactions during PDCoV infection.

Indexed as

Antiviral AgentsCalciumCoronavirus InfectionsDeltacoronavirusEndoplasmic Reticulum StressSwine DiseasesTriterpenesVirus ReplicationAnimalsPentacyclic TriterpenesSwineAntiviral AgentsCalciumcelastrolPentacyclic TriterpenesTriterpenesantiviral mechanismcalcium balancecelastrolendoplasmic reticulum stressporcine deltacoronavirus

Identifiers

PMID42366741
PMCPMC13311315

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.