ArticleInternational journal of tryptophan research : IJTR2026
Interaction of Hypoxia and Kynurenine Pathway in Periodontal Inflammation.
Article in International journal of tryptophan research : IJTR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The kynurenine pathway (KP), the primary route of tryptophan (TRP) metabolism, is influenced by inflammation and hypoxia and has been linked to immune dysregulation and oxidative stress. This study investigated the relationship between KP activity and hypoxia in periodontal inflammation, as well as their association with clinical periodontal parameters. A total of 23 systemically healthy patients with stage III, grade B periodontitis and 22 periodontally healthy individuals were included. Salivary and serum levels of tumor necrosis factor-alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured using ELISA. KP metabolites were analyzed via liquid chromatography-mass spectrometry. Results showed that salivary TNF-α, HIF-1α, and 8-OHdG levels were significantly higher in the periodontitis group (
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