ArticleInternational journal of chronic obstructive pulmonary disease2026
Chronic Obstructive Pulmonary Disease Influence on Lung Cancer Risk Through Blood Metabolite Mediation: A Two-Sample Mendelian Randomisation and Mediation Analysis.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Lung cancer (LC) risk is increased by chronic obstructive pulmonary disease (COPD) through metabolic and inflammatory processes. In addition to identifying possible inflammatory or blood metabolite mediators, this study explores the causal link between LC and COPD. Patients and Methods: To determine whether COPD and LC are causally related, as well as whether inflammatory variables and blood metabolites mediate this relationship, we used two-sample and two-step Mendelian randomization (MR) analyses based on summary data from published genome-wide association studies (GWAS). Directionality and robustness were investigated using reverse MR and sensitivity analyses, primarily using the inverse variance weighted (IVW) method. Results: Two-sample MR analyses revealed that COPD was a risk factor for the occurrence of LC ( Conclusion: These findings shed light on the underlying mechanisms that link COPD and LC and highlight the fact that COPD is a risk factor for the development of LC, with blood metabolites partially mediating this effect.
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