Platelet-rich plasma for the treatment of a pressure wound: a case report and review of the literature.

Introduction: Prolonged bed rest leads to pressure wounds with skin infections and difficulties in long-term wound healing. Platelet-rich plasma (PRP) contains high concentrations of platelets and is used to promote chronic wound healing. Objective: In this patient, PRP was used several times to promote the healing of a chronic pressure wound. Case Report: The patient presented with a decreased level of consciousness. Due to prolonged bed rest, a pressure wound and skin infection developed. The pressure wound was cleansed daily with iodophor, filled with alginate, and covered with a foam dressing for approximately 5 months; however, the wound did not heal. After assessment of the patient's physical condition, autologous PRP was used in the treatment. A total of 150 mL of peripheral blood was collected from the patient for the preparation of autologous PRP. After debridement, autologous PRP and an activator (thrombin and 10% calcium chloride) were mixed in a 10:1 volume ratio and sprayed onto the surface of the pressure wound, and was given a sterile oiled gauze and gauze coverage with foam dressing for protection. After eight PRP treatments, the pressure ulcer healed within 3 months. Conclusion: The patient's outcome suggests that PRP may be a promising adjunctive therapy for patients with nonhealing pressure ulcers.