ArticleCureus2026
Enhanced Apparent Oral Bioavailability of Berberine Through BioSOLVE Technology: Pharmacokinetic Evaluation of Metaberine™.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Berberine is an isoquinoline alkaloid known for its potential role in supporting metabolic, cardiovascular, and gastrointestinal functions. Its clinical application, however, remains constrained by limited oral absorption, which is influenced by factors such as low solubility, restricted intestinal permeability, metabolism, and transport-mediated efflux. Purpose This study compared the oral pharmacokinetics of Metaberine™, a novel berberine formulation developed with BioSOLVE technology, against conventional berberine in male rats. The objective was to determine whether the formulation enhances peak plasma concentration (C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.