Evidence map›Paper›PMID 42367743›Full record

ArticleInternational journal of mass spectrometry2026

Morphology Assessment Enabled by Room-Temperature Soft-Landing in Native MS.

Zihao Qi, Yu-Fu Lin, Sophie R Harvey, Joshua D Gilbert, Jared B Shaw, Austin Z Salome, Chen Du, Marius M Kostelic, Stella M Lai, Andrew J Arslanian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of mass spectrometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zihao QiNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Yu-Fu LinNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Sophie R HarveyNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Joshua D GilbertNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Jared B ShawDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588, United States.
Austin Z SalomeDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.
Chen DuNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Marius M KostelicNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Stella M LaiNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Andrew J ArslanianNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.
Joshua J CoonDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.
Vicki H WysockiNative MS Guided Structural Biology Center, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, United States.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
Native Mass Spectrometry Guided Structural Biology CenterRM1GM149374 · NIGMS · OHIO STATE UNIVERSITY · PI Vicki H. Wysocki · 2023 to 2026
$5.0M
NCI NIH HHS P30 CA016058NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM118110NIGMS NIH HHS RM1 GM149374
6 · The paper itself

Abstract

Native mass spectrometry (nMS) preserves non-covalent interactions, thereby maintaining native-like protein complex assemblies in the gas phase. Herein, the combination of nMS and room temperature ion soft-landing is assessed as a preparation technique for individual protein particle electron microscopy imaging. In this work, we first assessed Coon's room-temperature ion soft-landing setup by landing two selected protein complexes,

Identifiers

PMID42367743
PMCPMC13309228

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.