Evidence map›Paper›PMID 42367776›Full record

ArticleFrontiers in immunology2026

Lesion-specific features of macrophage polarization contribute to

Elena G Ufimtseva, Natalya I Eremeeva, Sergey N Skornyakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elena G UfimtsevaLaboratory of Medical Biotechnology, Institute of Biochemistry, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Natalya I EremeevaInstitute of Disinfectology, F.F. Erisman Federal Scientific Center of Hygiene of the Federal Service on Surveillance for Consumer Rights Protection and Human Well-being, Moscow, Russia.
Sergey N SkornyakovScientific Department, Ural Research Institute for Phthisiopulmonology, National Medical Research Center of Tuberculosis and Infectious Diseases of Ministry of Health of the Russian Federation, Yekaterinburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The innate immunity, linked to macrophage polarization, plays a critical role in the progression of tuberculosis (TB) disease caused by Methods: The expression of pro-inflammatory/anti-bacterial M1 cytokines (IFNγ, TNFα, IL-1β, and IL-12) and anti-inflammatory/immunosuppressive M2 cytokines (IL-4, IL-10, and FGF2) as well as activation of the AhR and NF- Results: Macrophage polarization was determined by local tissue microenvironments with varying fibrosis severity but was independent of Conclusions: The host cells' inability to eradicate

Indexed as

LungMacrophage ActivationMacrophagesMacrophages, AlveolarMycobacterium tuberculosisTuberculosis, PulmonaryAdultCytokinesFemaleHost-Pathogen InteractionsHumansMaleMiddle AgedSignal TransductionCytokinesAhR–AhRR–CYP1A1 axiscytokinesfibrosismixed M1/M2 polarizationMycobacterium tuberculosisNF-κB pathwaypulmonary tuberculosissmoker’s alveolar macrophages

Identifiers

PMID42367776
PMCPMC13303375

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.