Evidence map›Paper›PMID 42367922›Full record

ArticlebioRxiv : the preprint server for biology2026

Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.

Konstantin G Arbeev, Olivia Bagley, Joanne M Murabito, Harvey J Cohen, Brandon L Pierce, W Evan Johnson, Dan T A Eisenberg, Milind C Mahajan, Stacy L Andersen, Kaare Christensen and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Konstantin G ArbeevSocial Science Research Institute, Duke University, Durham, NC, USA.ORCID 0000-0002-4195-7832
Olivia BagleySocial Science Research Institute, Duke University, Durham, NC, USA.
Joanne M MurabitoThe Framingham Heart Study, Framingham, MA, USA.
Harvey J CohenCenter for the Study of Aging & Human Development and Duke Cancer Institute, Duke University, Durham, NC, USA.
Brandon L PierceDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
W Evan JohnsonCenter for Data Science, Rutgers University, New Jersey Medical School, Newark, NJ, USA.
Dan T A EisenbergDepartment of Anthropology, University of Washington, Seattle, WA, USA.
Milind C MahajanThe Genomic Center, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Stacy L AndersenDepartment of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
Kaare ChristensenThe Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-5429-5292
Joseph M ZmudaDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
Sheng LuoDepartment of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA.ORCID 0000-0003-4214-5809
Anatoliy I YashinSocial Science Research Institute, Duke University, Durham, NC, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Abraham AvivCenter of Human Development and Aging, New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0002-7441-0227

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI THOMAS T PERLS · 2019 to 2026
$125.4M
Impact of Phthalate Exposure on Telomere Biology in UteroR01ES035760 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABRAHAM AVIV, Whitney Cowell · 2024 to 2026
$1.1M
Telomere Length Measurements: Strengths and LimitationsU01AG066529 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI AVIV, ABRAHAM · 2019 to 2021
$911k
NIA NIH HHS U01 AG066529NIA NIH HHS U19 AG063893NIEHS NIH HHS R01 ES035760
6 · The paper itself

Abstract

Erythropoiesis is the most replication-intensive process in the body. Its lifelong replicative demands may erode hematopoietic cells' replicative capacity, leading to a decline in erythrocyte count (EC) in older adults and limiting their lifespan. We examined the relationship between EC and mortality among 1,620 participants aged ≥70 years in the Long Life Family Study and found that lower EC further augmented the exponential, age-dependent rise in mortality. We identified an EC threshold (ECT) (3.8×10

Identifiers

PMID42367922
PMCPMC13307930

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.