Evidence mapPaperPMID 42367939Full record

ArticlebioRxiv : the preprint server for biology2026

Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice.

Paola Montenegro, Rachel Kim, Mikayla Zedek, Marianna Chicas, Pamela Yeh, Hermes Yeh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paola MontenegroDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.ORCID 0000-0001-7521-1206
Rachel KimDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.
Mikayla ZedekDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.
Marianna ChicasDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.
Pamela YehDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.
Hermes YehDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth Hanover, NH 03755.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer's disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored. Mutations in the

Indexed as

Alzheimer’s diseaseAPP processingcortexhippocampusneurodevelopmentPresenilin 1γ-secretase

Identifiers

PMID42367939
PMCPMC13308066

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.