Systemic degradation of repressive transcription factors gates gene expression and cell fate specification.

Predrag Jevtić, Samuel R Witus, Devlon M McCloud, Zhi Yang, Ana Milunović Jevtić, Heegwang Roh, Michael Rapé

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Predrag JevtićDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Samuel R WitusDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Devlon M McCloudDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Zhi YangDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Ana Milunović JevtićDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Heegwang RohDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.

Michael RapéDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.ORCID 0000-0003-4849-6343

Funding

NCRR NIH HHS S10 RR025622NIH HHS S10 OD021828

6 · The paper itself

Abstract

While proteasomes are best known for eliminating defective proteins or turning off signaling pathways, they also enable crucial cellular activities. Critical among these, proteasomes allow cells to initiate gene expression, but underlying targets and regulatory mechanisms remain poorly understood. Here, we report that proteasomes drive the systemic degradation of repressive transcription factors to eject TLE/Groucho-family co-repressors from chromatin and thereby constantly free transcription start sites for activator binding. This circuitry requires the E3 ligase SCF

Indexed as

cancergene repressionproteasomequality controlstem cell differentiationubiquitin

Identifiers

PMID42367945

DOI10.64898/2026.06.16.732780

PMCPMC13308096

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.