Evidence map›Paper›PMID 42367974›Full record

ArticlebioRxiv : the preprint server for biology2026

A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I.

Ky'ara D Carr, Eliza O'Donnell, Tegan S Horan, Maame Serwaa Adjei-Boadu, Anna J Wood, Yongwei Zhang, Winfried Edelmann, Maria de Las Mercedes Carro, Paula E Cohen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ky'ara D CarrDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Eliza O'DonnellDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Tegan S HoranDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Maame Serwaa Adjei-BoaduDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Anna J WoodDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Yongwei ZhangDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Winfried EdelmannDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.
Maria de Las Mercedes CarroDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.
Paula E CohenDepartment of Biomedical Sciences and Cornell Reproductive Sciences Center (CoRe), Cornell University, Ithaca, NY 14853.ORCID 0000-0002-2050-6979

Funding

The MLH1-MLH3 Heterodimer in Mammalian Meiotic Recombination and GameogenesisR01HD041012 · NICHD · YESHIVA UNIVERSITY · PI Paula Elaine Cohen · 2003 to 2026
$7.9M
Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem CellsR01CA248536 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI EDELMANN, WINFRIED · 2021 to 2025
$2.0M
SLX4 as a mediator of crossover pathway decisions in mammalian meiosisR01HD097987 · NICHD · CORNELL UNIVERSITY · PI COHEN, PAULA ELAINE · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA248536NICHD NIH HHS R01 HD041012NICHD NIH HHS R01 HD097987
6 · The paper itself

Abstract

Meiotic recombination initiates with DNA double-strand breaks (DSBs) repaired as either crossovers (COs) or non-crossovers. Across eukaryotes, MSH4/MSH5 (MutSγ) licenses DSB repair intermediates, directing repair into the class I CO pathway via recruitment of MLH1/MLH3 (MutLγ). In mammals, excess MutSγ sites relative to final MutLγ foci suggest additional MutSγ functions, including directing repair through the minor class II CO pathway. We investigated the role of a mammalian-specific 38-amino acid C-terminal domain of MSH5 using mice lacking this domain (

Indexed as

CDK2CDK4crossoversdesignationlicensingMeiotic recombinationMutSγ

Identifiers

PMID42367974
PMCPMC13307971

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.