Evidence map›Paper›PMID 42368024›Full record

ArticlebioRxiv : the preprint server for biology2026

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

Trase Aguigam, Katarzyna Grab, Joanna Kowalska, Jacek Jemielity, John D Gross

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Trase AguigamTetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0009-0003-1034-8588
Katarzyna GrabDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-095, Warsaw, Poland.ORCID 0000-0001-8294-2808
Joanna KowalskaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-095, Warsaw, Poland.ORCID 0000-0002-9174-7999
Jacek JemielityCentre of New Technologies, University of Warsaw, 02-097, Warsaw, Poland.ORCID 0000-0001-7633-788X
John D GrossTetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-1377-4705

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Molecular Mechanisms that Control mRNA Decapping in Biological CondensatesR01GM148881 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John D Gross · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R01 GM148881
6 · The paper itself

Abstract

Removal of the 5' m

Indexed as

autoinhibitionbiomolecular condensatesDcp1/Dcp2intrinsically disordered regionsmRNA decappingsequence motifs

Identifiers

PMID42368024
PMCPMC13307997

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.