ArticleACS omega2026
Synthesis, Structural Characterization and Reactivity of Macrocyclic Cyclo[2]malonates.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
We report the controlled synthesis of a new class of oxygen-bridged cyclo[2]-malonates via condensation of malonyl dichloride with substituted benzylic α,ω-diols. Optimization of reaction conditions enables selective access to dimeric macrocycles, overcoming the intrinsic tendency toward higher oligomer formation. Single-crystal X-ray diffraction reveals well-defined conformations, tunable cavity sizes, and substituent-dependent stereochemical preferences. The macrocycles assemble into interlocked columnar architectures driven by shape complementarity and stabilized by C-H···O hydrogen bonding, with additional halogen bonding in iodinated derivatives. While α-proton acidity is retained across the series, vanadyl (VO
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