Evidence map›Paper›PMID 42368247›Full record

ArticleBlood. Red cells & iron2026

Newborns with sickle cell trait have distinct peripheral blood molecular signatures across the first week of life.

Abhinav K Checkervarty, Casey P Shannon, Travis M Blimkie, Bhavjinder K Dhillon, Reza Falsafi, Asimenia Angelidou, Joann Diray-Arce, Tue B Bennike, Natasha M Archer, Olubukola T Idoko and 13 more

Abstract read
In one paragraph

Article in Blood. Red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Abhinav K CheckervartyPROOF (Prevention of Organ Failure) Centre of Excellence, Providence Research, Providence Health Care, Vancouver, BC, Canada.ORCID 0000-0002-1032-9198
Casey P ShannonPROOF (Prevention of Organ Failure) Centre of Excellence, Providence Research, Providence Health Care, Vancouver, BC, Canada.ORCID 0000-0002-5687-3156
Travis M BlimkieDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0001-8778-8627
Bhavjinder K DhillonDepartment of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-9696-1556
Reza FalsafiDepartment of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada.
Asimenia AngelidouPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0002-6716-6561
Joann Diray-ArcePrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0003-2183-4269
Tue B BennikeHarvard Medical School, Boston, MA.ORCID 0000-0003-4354-1731
Natasha M ArcherHarvard Medical School, Boston, MA.
Olubukola T IdokoVaccines and Immunity Theme, Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID 0000-0002-8802-2946
Kerry McEnaneyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0002-0378-3456
Al OzonoffPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0003-4233-5899
Oludare A OdumadePrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0002-8630-8510
Rym Ben-OthmanRAN BioLinks Ltd, Richmond Hill, ON, Canada.ORCID 0000-0002-7245-6854
Kinga K SmolenPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0001-8650-3693
Hanno SteenPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0003-0179-6648
EPIC-HIPC Consortium
Beate KampmannVaccines and Immunity Theme, Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID 0000-0002-6546-4709
Tobias R KollmannDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-2403-9762
Ofer LevyPrecision Vaccines Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA.ORCID 0000-0002-5859-1945
Amy H LeeDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0003-3250-3246
Robert E W HancockDepartment of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5989-8503
Scott J TebbuttPROOF (Prevention of Organ Failure) Centre of Excellence, Providence Research, Providence Health Care, Vancouver, BC, Canada.ORCID 0000-0002-7908-1581

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
Proteomics and Metabolomics Core: IDEAL shapes vaccine response, susceptibility to respiratory infectious disease and asthmaU19AI168643 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI OFER LEVY · 2022 to 2026
$10.0M
NIAID NIH HHS U19 AI118608NIAID NIH HHS U19 AI168643
6 · The paper itself

Abstract

Sickle cell trait (SCT) is a genetic condition characterized by a heterozygous A-T substitution (Glu to Val) in 1 copy of the β-globin (

Identifiers

PMID42368247
PMCPMC13309152

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.