Evidence map›Paper›PMID 42368562›Full record

ArticleActa pharmaceutica Sinica. B2026

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (ROR

Patrik F Schwarz, Alexander F Perhal, Teresa Preglej, Lina Breit, Klaus G Schmetterer, Ulrike Grienke, Jasmin Janneschütz, Ya Chen, Natacha Rochel, Johannes Kirchmair and 4 more

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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Patrik F SchwarzDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Alexander F PerhalDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Teresa PreglejDepartment of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna 1090, Austria.
Lina BreitDepartment of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna 1090, Austria.
Klaus G SchmettererDepartment of Laboratory Medicine, Medical University of Vienna, Vienna 1090, Austria.
Ulrike GrienkeDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Jasmin JanneschützVienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna 1090, Austria.
Ya ChenDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Natacha RochelInstitute of Genetics and Molecular and Cellular Biology (IGBMC), INSERM, U1258/CNRS, UMR 7104/Univ. Strasbourg, Illkirch 67404, France.
Johannes KirchmairDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Nina SchützenmeisterDepartment of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Judith M RollingerDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.
Michael BonelliDepartment of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna 1090, Austria.
Verena M DirschDepartment of Pharmaceutical Sciences, Division of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Vienna 1090, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout history, herbal medicines and natural products have played a crucial role as therapeutics for humans, yet their molecular mechanisms of action often remain elusive. Here, we investigate whether primulagenin A (PGA) from the traditionally used herbal substance Primula root acts

Indexed as

IL-17ANatural productsPrimulae radixPrimulagenin ARORγ (ROR gamma)Structure–activity relationshipTh17 cellsTriterpenoids

Identifiers

PMID42368562
PMCPMC13305163

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.