Evidence map›Paper›PMID 42369023›Full record

ArticleRegenerative biomaterials2026

Three-dimensionally-printed biphasic PCL/

Feng Zhou, Xiaoyun Pan, Qixiang Yin, Xiao Yang, Xiangdong Zhu, Maria Grazia Raucci, Luigi Ambrosio, Xingdong Zhang, Jingyi Mi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feng ZhouSuzhou Medical College of Soochow University, Suzhou 215123, China.
Xiaoyun PanWuxi Ninth People's Hospital, Affiliated to Soochow University, Wuxi 214000, China.
Qixiang YinDepartment of Emergency Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Xiao YangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.ORCID https://orcid.org/0000-0001-7248-8218
Xiangdong ZhuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Maria Grazia RaucciInstitute of Polymers, Composites and Biomaterials, National Research Council, Naples 80072, Italy.
Luigi AmbrosioInstitute of Polymers, Composites and Biomaterials, National Research Council, Naples 80072, Italy.
Xingdong ZhangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Jingyi MiWuxi Ninth People's Hospital, Affiliated to Soochow University, Wuxi 214000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral defects remain difficult to repair because articular cartilage and subchondral bone differ in structure and regenerative capacity, and stable interface integration is challenging. Here, we developed a structurally continuous yet functionally stratified biphasic scaffold via dual-temperature 3D printing, consisting of a poly(ε-caprolac tone)/β-tricalcium phosphate (PCL/β-TCP) bone-mimetic phase with larger macropores and a pure PCL cartilage-guiding phase with smaller pores. A GelMA/chondroitin sulfate (GelMA/CS) hydrogel was selectively infiltrated into the upper region by immersion and photocrosslinking, while a ∼0.5 mm hydrogel-free transitional zone was preserved as a structural transition region between the chondral hydrogel compartment and the subchondral scaffold.

Indexed as

3D printingbiphasic scaffoldosteochondral defectPI3K–AKT signalingTRPV4

Identifiers

PMID42369023
PMCPMC13303298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.