Evidence map›Paper›PMID 42369230›Full record

ArticleScientifica2026

Herbal Formula IM-B Possesses Antioxidant Activities and Reduces Expression of Proinflammatory Cytokines in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Nuttikarn Nokkaew, Ngamrayu Ngamdokmai, Kittikun Viwatpinyo, Pipob Suwanchaikasem, Woraanong Prugsakij, Parnthep Pourpongpan, Sakan Warinhomhoun

Abstract read
In one paragraph

Article in Scientifica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nuttikarn NokkaewSchool of Pharmacy, Walailak University, Thai Buri, Nakhon Si Thammarat, 80160, Thailand, wu.ac.th.ORCID https://orcid.org/0000-0002-5165-0025
Ngamrayu NgamdokmaiFaculty of Pharmaceutical Sciences, Burapha University, Chonburi, 20131, Thailand, buu.ac.th.ORCID https://orcid.org/0000-0002-1435-7719
Kittikun ViwatpinyoHerbology Research Center, Walailak University, Thai Buri, Nakhon Si Thammarat, 80160, Thailand, wu.ac.th.ORCID https://orcid.org/0000-0003-1802-023X
Pipob SuwanchaikasemBaiya Phytopharm Co., Ltd., Chulalongkorn University, Bangkok, 10330, Thailand, chula.ac.th.ORCID https://orcid.org/0000-0001-7991-6414
Woraanong PrugsakijCollege of Integrative Medicine, Dhurakij Pundit University, Bangkok, 10210, Thailand, dpu.ac.th.ORCID https://orcid.org/0009-0006-2401-1742
Parnthep PourpongpanCollege of Oriental Medicine, Rangsit University, Lak Hok, Pathum Thani, 12000, Thailand, rsu.ac.th.
Sakan WarinhomhounHerbology Research Center, Walailak University, Thai Buri, Nakhon Si Thammarat, 80160, Thailand, wu.ac.th.ORCID https://orcid.org/0000-0003-0299-6975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IM-B is a herbal formula comprising extracts derived from four medicinal herbs previously reported to exhibit antioxidant and anti-inflammatory properties. In this study, the bioactive compounds of IM-B extract, as well as its antioxidant and anti-inflammatory properties, were explored. Chemical compounds in IM-B extract were identified through phytochemical analysis using LC-ESI-QTOF-MS/MS. Fifteen compounds comprising naringenin 5-methyl ether, alpinetin, pinocembrin, 2',4',6'-trihydroxydihydrochalcone, demethoxycurcumin, curcumin, alpinetin methyl ether, caffeic acid, myrcene, bisdemethoxycurcumin, geraniol, pinostrobin, pinostrobin chalcone, cannabidiol, and astaxanthin were analyzed. Based on the total phenolic (106.20 ± 3.11 mg GAE/g extract) and flavonoid (94.65 ± 2.65 mg QE/g extract) contents of the IM-B extract, we consider it a good source of these secondary metabolites. Its antioxidant activities were 4.03 ± 0.63 μg/mL, 9.11 ± 0.57 μg/mL, and 126.84 ± 0.30 mg FeSO

Indexed as

anti-inflammationantioxidantherbal formulaIM-B formulaRAW 264.7 macrophage cells

Identifiers

PMID42369230
PMCPMC13305134

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.