ArticleFrontiers in neurology2026
Impact of the triglyceride-glucose index on prognosis following endovascular therapy for acute ischemic stroke: effect modification by collateral circulation.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the association between the triglyceride-glucose (TyG) index and 90-day functional outcome after endovascular therapy in patients with acute ischemic stroke, to evaluate the risk assessment performance of the TyG index combined with clinical variables, and to assess the effect-modifying role of collateral circulation in this association. Methods: A retrospective analysis was conducted in 209 patients with acute ischemic stroke who underwent endovascular therapy at our hospital between October 2022 and December 2025. Multivariable logistic regression was performed to evaluate factors associated with poor functional outcome, defined as a modified Rankin Scale (mRS) score > 2 at 90 days. Interaction and stratified analyses were conducted to assess whether collateral circulation modified the association between the TyG index and clinical outcomes. Receiver operating characteristic (ROC) curves and the corresponding area under the curve (AUC) were used to evaluate the predictive performance of the TyG index combined with clinical variables. Differences in AUCs were compared using DeLong's test. Calibration was assessed using the Hosmer-Lemeshow test, Brier score, and calibration curve, and internal validation was performed with 1,000 bootstrap resamples. Results: A total of 209 patients were included, with 145 (69.4%) in the good functional outcome group (modified Rankin Scale [mRS] score≤2) and 64 (30.6%) in the poor functional outcome group (mRS > 2). Univariate analysis showed that the TyG index was significantly higher in the poor functional outcome group, and that sex, baseline National Institutes of Health Stroke Scale (NIHSS) score and collateral circulation status also differed significantly between the two groups (all Conclusion: The TyG index is an independent risk factor for poor 90-day functional outcome after endovascular therapy in patients with acute ischemic stroke. Collateral circulation may modify this association. The TyG index also improves the risk assessment performance of the combined risk model.
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