Evidence map›Paper›PMID 42369438›Full record

ArticleNAM journal2025

Next-generation risk assessment: Integrating

Francisco da Silva Rezende, Leonardo Pinto, Antônio Anax Oliveira Falcão, Ana Carolina Cavalheiro Paulelli, Renata Mazaro-Costa, Natália Valadares de Moraes, Fernanda de Lima Moreira

Abstract read
In one paragraph

Article in NAM journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francisco da Silva RezendeLaboratory of Pharmacometrics (LabFarma), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Leonardo PintoLaboratory of Pharmacometrics (LabFarma), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Antônio Anax Oliveira FalcãoAima Toxicologia, São Paulo, SP, Brazil.
Ana Carolina Cavalheiro PaulelliLaboratory of Pharmacometrics (LabFarma), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Renata Mazaro-CostaDepartamento de Farmacologia - Instituto de Ciências Biológicas - Universidade Federal de Goiás, GO, Brazil.
Natália Valadares de MoraesCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL, USA.
Fernanda de Lima MoreiraLaboratory of Pharmacometrics (LabFarma), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognizing the need of implementing new approach methodologies (NAMs) in the pharmaceutical industry to establish health-based limits, this study employs an innovative strategy for deriving the permitted daily exposure (PDE) value, using vancomycin as a study case. We integrated

Indexed as

BMDLNAMPDEToxicokinetics

Identifiers

PMID42369438
PMCPMC13289197

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.