Evidence mapPaperPMID 42369449Full record

ReviewOncology reviews2026

Cardio-oncology in multidisciplinary synergy: addressing the rising burden of cancer therapy-related cardiovascular toxicity (CTR-CVT) in advancing oncology practices.

Putri Dwi Astuti, Eko Adhi Pangarsa, Andreas Arie Setiawan, Daniel Rizky, Budi Setiawan, Charles Limantoro, Damai Santosa, Catharina Suharti

Abstract readReview
In one paragraph

Review in Oncology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Putri Dwi AstutiDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Eko Adhi PangarsaDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Andreas Arie SetiawanDepartment of Cardiovascular, Dr. Kariadi General Hospital, Semarang, Indonesia.
Daniel RizkyDivision of Hematology and Medical Oncology, Department of Oncology, Dr. Kariadi General Hospital, Semarang, Indonesia.
Budi SetiawanDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Charles LimantoroDepartment of Cardiovascular, Dr. Kariadi General Hospital, Semarang, Indonesia.
Damai SantosaDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Catharina SuhartiDivision of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Improvements in cancer detection and the development of modern anticancer therapies have markedly increased survival rates among patients with malignancies, resulting in a rapidly expanding survivor population. Alongside these advances, cardiovascular complications related to cancer treatment have emerged as a major clinical concern, significantly affecting long-term morbidity and mortality. The growing intersection between oncology and cardiovascular medicine has led to the development of cardio-oncology, a multidisciplinary field focused on balancing effective cancer treatment with cardiovascular safety. This review discusses current perspectives on the mechanisms, risk assessment, prevention, surveillance, and management of cancer therapy-related cardiovascular toxicity (CTR-CVT) in contemporary oncology practice. Methods: A narrative literature review was conducted using electronic databases including PubMed, Scopus, and ScienceDirect. Relevant studies published between 2015 and 2025 were identified using predefined keywords related to cardio-oncology and cardiovascular toxicity. Eligible articles included clinical trials, observational studies, guidelines, and systematic reviews focusing on CTR-CVT. Studies were screened based on relevance, and key findings were synthesized narratively. Key-content and findings: CTR-CVT comprises diverse cardiovascular complications associated with both conventional and emerging anticancer therapies. Risk stratification tools such as HFA-ICOS facilitate early identification of high-risk patients and guide surveillance strategies. Early multidisciplinary management, particularly for severe toxicities such as immune checkpoint inhibitor-associated myocarditis, is essential to optimize both cardiovascular and oncologic outcomes. Conclusion: CTR-CVT represents a major challenge in contemporary oncology care. A multidisciplinary cardio-oncology approach integrating early risk assessment, preventive strategies, and structured monitoring is essential to balance oncologic efficacy with cardiovascular safety. Future research should focus on personalized risk prediction and targeted cardioprotection strategies.

Indexed as

cancer therapycardio-oncologycardiovascular toxicitymultidisciplinary carerisk stratification

Identifiers

PMID42369449
PMCPMC13303625

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.