Evidence map›Paper›PMID 42370174›Full record

ArticleTheranostics2026

Ultra-high-field magnetic resonance imaging reveals sex-specific recovery after ischemic stroke following treatment with three-dimensional human mesenchymal stem cell-derived extracellular vesicles.

Jamini Bhagu, Arshia Arbabian, Thurston Da Vitoria Lobo, Katherine Martinez, Dayna L Richter, Hannah Bryant, Malathy Elumalai, Yan Li, Samuel C Grant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jamini BhaguNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Arshia ArbabianNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Thurston Da Vitoria LoboNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Katherine MartinezNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Dayna L RichterNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Hannah BryantNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Malathy ElumalaiNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Yan LiNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.
Samuel C GrantNational High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA.

Funding

Engineering Extracellular Vesicles of Human Brain Organoids for Stroke TherapyR01NS125016 · NINDS · FLORIDA STATE UNIVERSITY · PI Yan Li · 2022 to 2026
$1.8M
NINDS NIH HHS R01 NS125016
6 · The paper itself

Abstract

rationaleIschemic stroke is sexually dimorphic. Biological sex can influence injury progression and response to treatment. Extracellular vesicles (EV) derived from three-dimensional (3D) human mesenchymal stem cell aggregates (3D-EV) are a promising candidate as a treatment, but their efficacy across these biological variables and

methodsA preclinical model of transient middle cerebral artery occlusion was used to longitudinally evaluate the efficacy of ultrasmall superparamagnetic iron oxide (USPIO)-labeled 3D-EV or saline at reperfusion through intra-arterial injection. MRI was performed at 21.1 T, which included T

resultsUSPIO-labeled 3D-EV resulted in localized hypointense contrast in the ischemic striatum, indicating delivery of treatment. T

conclusions3D-EV therapy showed trends toward structural, ionic, and metabolic recovery following an ischemic insult. Ultra-high-field MRI and MRS can provide sensitive biomarkers to resolve these differences and support 3D-EV as a potential cell-free therapeutic candidate for ischemic stroke.

Indexed as

Extracellular VesiclesIschemic StrokeMagnetic Resonance ImagingMesenchymal Stem CellsAnimalsDisease Models, AnimalFemaleHumansMaleagingdiffusion MRIextracellular vesiclesischemic strokemesenchymal stem cellssex differencessodium MRI

Identifiers

PMID42370174
PMCPMC13295759

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.