Evidence map›Paper›PMID 42370197›Full record

ArticleTheranostics2026

Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia-Reperfusion Injury.

Peng Qu, Jiao Shi, Xue Li, Yao Gu, Jun Liu, Hongyan Zhang, MingZhi Zhou, Cui Ma, Xinghui Li, Wenjie Tian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peng QuDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Jiao ShiDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Xue LiDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Yao GuDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Jun LiuInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Hongyan ZhangDepartment of Anesthesiology, Chengdu Wenjiang District People's Hospital, Chengdu 611130, China.
MingZhi ZhouInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Cui MaDepartment of Mathematics, Army Medical University, Chongqing 400038, China.
Xinghui LiDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Wenjie TianInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Qi LiangDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Gang LiInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Panke ChengInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of myocardial ischemia-reperfusion (MI/R) injury is intricately linked to mitochondrial dysfunction occurring during both the ischemic and reperfusion phases. Through single-cell transcriptome analysis, we identified a subpopulation of HEY1-high expressing cardiomyocytes (HEY1

Indexed as

MitochondriaMyocardial Reperfusion InjuryMyocytes, CardiacAnimalsDisease Models, AnimalMaleMicroneedle Drug DeliverySwineSwine, MiniatureATP5BHEY1Ischemia-reperfusion injuryMicroneedlesP5CS

Identifiers

PMID42370197
PMCPMC13294972

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.