ReviewFrontiers in molecular neuroscience2026
Voluntary wheel exercise reduces pain behavior by modulating neuroinflammation in neuropathic pain.
Review in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Neuropathic pain (NP) is a common condition caused by injury or disease of the somatosensory nervous system. It is associated with excessive inflammation of the central and peripheral nervous system. The treatment of NP is extremely challenging. In recent years, exercise therapy has received extensive research attention. Voluntary wheel running (VWR) is a simple aerobic exercise commonly used in animal experiments. VWR-induced analgesia seems to be associated with re-establishment of the neuroinflammatory system. This paper discusses the effects of VWR on the inflammatory response of the nervous system, including the brain, spinal cord, dorsal root ganglia (DRG), and peripheral nerves involved in NP regulation. VWR works by decreasing pro-inflammatory cytokines in the brain, spinal cord, DRG, and peripheral nerves, as well as by increasing anti-inflammatory cytokines to show anti-inflammatory effects. VWR also decreases the expression of glial cells in the brain, spinal cord, and DRG and modulates neuroinflammation. This study reviews the mechanisms by which VWR modulates neuroinflammation in NP to reduce pain behaviors and improve our understanding of the VWR role in NP treatment.
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