Evidence map›Paper›PMID 42370240›Full record

ArticleResearch square2026

Gain-of-function PfAAT1 mutations compensate for impaired PfCRT function in

Muhammad M Hasan, Eva S Istvan, Jack Farah, Kharizta Wiradiputri, Sydney Gavula, Elizabeth A Winzeler, Manuel Llinás, David A Fidock, Daniel E Goldberg

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad M HasanDivision of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.
Eva S IstvanDivision of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.ORCID 0000-0002-8666-3248
Jack FarahDivision of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.
Kharizta WiradiputriDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, NY, USA.
Sydney GavulaHuck Center for Malaria Research (CmaR), The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0009-0001-1613-3292
Elizabeth A WinzelerDepartment of Pediatrics, University of California, San Diego, La Jolla, CA USA.
Manuel LlinásHuck Center for Malaria Research (CmaR), The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-6173-5882
David A FidockDepartment of Microbiology & Immunology, Columbia University Irving Medical Center, NY, USA.ORCID 0000-0001-6753-8938
Daniel E GoldbergDivision of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.ORCID 0000-0003-3529-8399

Funding

Defining the resistome in P. falciparum: evolution and mechanismR01AI169892 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Daniel E. Goldberg, Elizabeth A Winzeler · 2023 to 2026
$4.4M
Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4M
NIAID NIH HHS R01 AI169892NIAID NIH HHS R37 AI050234
6 · The paper itself

Abstract

Mutations in the chloroquine resistance transporter (PfCRT) confer resistance to chloroquine (CQ) in the malaria parasite

Identifiers

PMID42370240
PMCPMC13308367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.