ArticleResearch square2026
Gentrification and Cognitive Aging: Examining Neighborhood Change and Cognitive Decline in Older Adults in the Multi-Ethnic Study of Atherosclerosis.
Yvonne L Michael, Kari Moore, Lilah M Besser, Timothy M Hughes, Reyhaneh Akbar Nejad Yazdi, Kathleen M Hayden, Jana A Hirsch
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In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Kari MooreDrexel University Dornsife School of Public Health.
Lilah M BesserUniversity of Miami Miller School of Medicine: University of Miami School of Medicine.
Timothy M HughesWake Forest University School of Medicine.
Reyhaneh Akbar Nejad YazdiDrexel University Dornsife School of Public Health.
Kathleen M HaydenTrinity College Dublin: The University of Dublin Trinity College.
Jana A HirschDrexel University Dornsife School of Public Health.
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MLongitudinal Neighborhood Determinants of ADRD Progression within a Multi-Site CohortR01AG072634 · NIA · DREXEL UNIVERSITY · PI Jana Ariel Hirsch · 2021 to 2026
$6.1MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MNeighborhoods and CVD Risk in a Multiethnic Cohort (RMI)R01HL071759 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2003 to 2013
$4.8MTO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4MThe Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCADR01AG054069 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M. · 2016 to 2020
$3.8MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL071759NHLBI NIH HHS R01 HL131610NIA NIH HHS R01 AG054069NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG072634
6 · The paper itselfAbstract
We examined whether neighborhood gentrification is associated with cognitive change among older adults in the Multi-Ethnic Study of Atherosclerosis (MESA; n = 1,731). Among participants, 23% resided in continually advantaged neighborhoods, 34% in gentrified neighborhoods, and 43% in continually disadvantaged neighborhoods (2000-2010). A Global Cognitive Composite (GCC) assessed memory, processing speed, and executive function from 2010-2024. Linear mixed-effects models with inverse probability weights estimated cognitive change over 5 years. After adjustment for confounding, GCC declined most in gentrified neighborhoods (- 0.15 SD) and least in continually advantaged neighborhoods (- 0.12 SD), with intermediate decline in continually disadvantaged neighborhoods (- 0.13 SD; p = 0.06). Neighborhood-level change may not confer cognitive protection and could carry risks, even relative to persistently disadvantaged contexts.
Indexed as
Cognitive functionGentrificationHealth inequitiesNeighborhood advantageOlder adult
Identifiers
PMID42370256
PMCPMC13308368
What Socratic holds
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