ArticleFrontiers in nutrition2026
Effects of low glycemic index/load diets on metabolic and inflammatory markers in humans: a meta-analysis.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
Objective: To evaluate the potential associations between low glycemic index (LGI) and low glycemic load (LGL) diets and variations in body weight, lipid profiles, and inflammatory markers through a meta-analysis. Methods: Systematic searches were conducted in PubMed, Cochrane Library, EMBASE, Web of Science, and Google Scholar for randomized controlled trials (RCTs) published through November 2025 (PROSPERO: CRD420251247827). Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were estimated using random-effects or fixed-effects models. Results: 21 RCTs ( Conclusion: Current evidence suggests that LGI/LGL diets may favorably modulate body weight, lipid metabolism, and specific inflammatory markers. Nevertheless, these pooled estimates must be interpreted with extreme caution due to profound inter-study heterogeneity, suboptimal methodological quality of the included trials, and the statistical instability of TNF-α and IL-6. Consequently, this meta-analysis underscores the limitations of the existing literature rather than establishing definitive clinical efficacy.
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