Evidence mapPaperPMID 42370539Full record

ArticleMicrobiology and immunology2026

Pipa Qingfei Yin Ameliorates Acne Inflammation in Mice via Suppressing Neutrophil Extracellular Traps.

Liangyi Wang, Xiaodan Wu, Meihui Qi, Shihua Zhang

Abstract read
In one paragraph

Article in Microbiology and immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liangyi WangDepartment of Traditional Chinese Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.ORCID https://orcid.org/0009-0003-1090-0416
Xiaodan WuDepartment of Traditional Chinese Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Meihui QiDepartment of Traditional Chinese Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Shihua ZhangDepartment of Traditional Chinese Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.

Funding

the Doctoral Startup Program of the Liaoning Provincial Department of Science and Technology 2025080350-JH3/101
6 · The paper itself

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit driven by Cutibacterium acnes colonization and the ensuing inflammatory response. Neutrophil extracellular traps (NETs) play a critical role in acne inflammation. Pipa Qingfei Decoction (PPQFY), a classic Traditional Chinese Medicine formula for acne, exhibits antibacterial and anti-inflammatory effects, but whether it regulates NETs to alleviate Cutibacterium-induced acne remains unclear. In vitro (keratinocytes/neutrophils) and in vivo (C57BL/6 mice) acne models were established using Cutibacterium acnes and treated with PPQFY, DNase I, or GSK484 (NET inhibitors). Neutrophil purity and Ly6G

Indexed as

Acne VulgarisAnti-Inflammatory AgentsDrugs, Chinese HerbalExtracellular TrapsInflammationNeutrophilsAnimalsCell ProliferationCell SurvivalDisease Models, AnimalHumansInterleukin-1betaKeratinocytesMiceMice, Inbred C57BLPropionibacterium acnesAnti-Inflammatory AgentsDrugs, Chinese HerbalInterleukin-1betaTumor Necrosis Factor-alphaAcne vulgariscutibacterium acnesneutrophil extracellular trapspipaqingfei Yinskin inflammation

Identifiers

PMID42370539
PMCPMC13441035

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.