Evidence map›Paper›PMID 42370554›Full record

ReviewNatural product reports2026

Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration.

Hye Jin Kim, Janet R Sparrow, Young Pyo Jang

Abstract readReview
In one paragraph

Review in Natural product reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hye Jin KimCollege of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.
Janet R SparrowDepartment of Ophthalmology, Columbia University Medical Center, 701 W., 168th St, New York, NY 10032, USA. Jrs88@columbia.edu.
Young Pyo JangDepartment of Integrated Drug Development and Natural Products, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID http://orcid.org/0000-0001-5865-9228

Funding

IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLSR01EY012951 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2000 to 2024
$8.9M
NEI NIH HHS R01 EY012951
6 · The paper itself

Abstract

Covering: up to 2026Bisretinoids are a chemically distinct class of endogenous natural products formed by the non-enzymatic condensation of visual-cycle retinoids. Derived from dietary provitamin A carotenoids

Indexed as

Biological ProductsRetinal DegenerationRetinoidsHumansMolecular StructurePhotochemical ProcessesRetinaldehydeRetinal Pigment EpitheliumBiological ProductsRetinaldehydeRetinoids

Identifiers

PMID42370554
PMCPMC13312781

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.