Evidence map›Paper›PMID 42370695›Full record

ArticlemSystems2026

Transcriptomics profiles in intestinal sulfide overproduction, small intestinal bacterial overgrowth, and intestinal methanogen overgrowth.

Juliana de Freitas Germano, Gabriela Leite, Maria Jesus Villanueva-Millan, Daniel Brimberry, Mohamad Rashid, Ava Hosseini, Dilara Flor, Said Bogatyrev, Walter Morales, Stacy Weitsman and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Juliana de Freitas GermanoMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.ORCID 0000-0001-5924-2483
Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Maria Jesus Villanueva-MillanMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Daniel BrimberryMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Mohamad RashidMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Ava HosseiniMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Dilara FlorMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Said BogatyrevMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Walter MoralesMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Stacy WeitsmanMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Maritza SanchezMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Ignacio RiveraMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Cristina Moreno FajardoMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Victoria MurrayMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Gonzalo ParodiMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Margie ParraMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Zhe LyuDepartment of Plant and Microbial Biology, North Carolina State University, Raleigh, North Carolina, USA.
Gillian M BarlowMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.ORCID 0000-0002-0487-048X
Ali RezaieMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.
Mark PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, California, USA.ORCID 0000-0002-0619-5115

Funding

Elia, Genevieve, and Georgianna Atol Charitable TrustMonica Lester Charitable TrustScott Gray FoundationSteve Perry Foundation
6 · The paper itself

Abstract

Despite advances in identifying distinct microbial profiles linked to intestinal sulfide overproduction (ISO), small intestinal bacterial overgrowth (SIBO), and intestinal methanogen overgrowth (IMO), differences in host small bowel (SB) gene expression remain unexplored. Therefore, we compared host gene transcriptomics in SB biopsies from subjects with IMO, ISO, and SIBO. Separately, SB transcriptomics in rats gavaged with hydrogen sulfide (H

Indexed as

BacteriaIntestine, SmallMethaneSulfidesTranscriptomeAdultAnimalsFemaleGene Expression ProfilingHumansHydrogen SulfideMaleRatsHydrogen SulfideMethaneSulfideshydrogen sulfideimmunoregulationintestinal methanogen overgrowthintestinal sulfide overproductionmethanemitochondrial functionredox balancesmall bowelsmall intestinal bacterial overgrowthtranscriptomics

Identifiers

PMID42370695
PMCPMC13386965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.