Evidence map›Paper›PMID 42370710›Full record

ArticleJournal of bacteriology2026

Development of a gene-editing strategy to overcome genetic intractability in

Keerthikka Ravi, Nicole R Falkowski, Gary B Huffnagle

Abstract read
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Keerthikka RaviDepartment of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-7393-0936
Nicole R FalkowskiDepartment of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Gary B HuffnagleDepartment of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4505-9642

Funding

Mary H Weiser Food Allergy CenterNational Institute of Allergy and Infectious Diseases R01AI138348Nina and Jerry D. Luptak Endowment
6 · The paper itself

Abstract

Genetic editing in lactobacilli is often constrained by their robust defense mechanisms against foreign DNA and low transformation efficiency, resulting in pronounced species- and strain-specific variability in the performance of genetic tools. In this study, we developed a markerless gene editing system for

Indexed as

Gene EditingLactobacillus johnsoniiAnimalsDrug Resistance, BacterialFluorouracilMicePentosyltransferasesPlasmidsFluorouracilPentosyltransferasesuracil phosphoribosyltransferase5-fluorouracilbeta-galactosidasemarkerlesstransformation efficiencyupp

Identifiers

PMID42370710
PMCPMC13393412

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.