Evidence map›Paper›PMID 42371045›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Ethyl ferulate attenuates allergic asthma via inhibiting macrophage M2 polarization through STAT6/IRF4 pathway.

Longlong Ge, Weizhen Chen, Shuguang Han, Huan Yang, Mingchen Du, Shengpeng Li, Xinran Bai, Peilin Zhao, Dan Chen, Qingfeng Pang and 1 more

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Longlong Ge *Wuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Weizhen Chen *School of Pharmacy, Anhui College of Traditional Chinese Medicine, Wuhu, 241000, Anhui Province, People's Republic of China.
Shuguang Han *Department of Respiratory and Critical Care Medicine, Jiangnan University Medical Center, 68 Zhongshan Road, Wuxi, 214002, Jiangsu Province, People's Republic of China.
Huan YangWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Mingchen DuWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Shengpeng LiWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Xinran BaiWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Peilin ZhaoWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Dan ChenWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Qingfeng PangWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Yaxian WuWuxi School of Medicine, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, Jiangsu Province, People's Republic of China. yaxianwu@jiangnan.edu.cn.

Funding

Domestic Study and Research Visit Program for Young Key Teachers in Anhui Province JNFX2024104National Natural Science Foundation of China 82100018Natural Science Foundation of Jiangsu Province BK20200602
6 · The paper itself

Abstract

objectiveAllergic asthma is a chronic airway inflammatory disease with limited therapeutic options in clinical practice. Ethyl ferulate (EF), a natural compound commonly found in Chuanxiong, Danggui and grains, has been shown to possess multiple biological activities. However, the effect of EF on allergic asthma and its underlying mechanisms remains unclear. This study aimed to investigate the therapeutic potential and mechanism of EF in allergic asthma.

methodsThe house dust mite (HDM)-induced allergic asthma mouse model was used to evaluate the effects of EF on airway inflammation and macrophage M2 polarization. Adoptive transfer experiments were used to confirm the critical role of M2 polarization in the attenuation of allergic asthma by EF. Mechanistic studies were performed by using IL-4-stimulated RAW264.7 cells and bone marrow-derived macrophages (BMDMs).

resultsEF significantly attenuated HDM-induced airway inflammation, eosinophil infiltration, mucus secretion, and airway remodeling. EF suppressed M2 macrophage markers (CD206, Arg1, Ym1, Fizz1) in lung tissues and IL-4-stimulated macrophages. Mechanistically, EF blocked STAT6 phosphorylation and nuclear translocation, thereby inhibiting the STAT6/IRF4 pathway.

conclusionsEF alleviates allergic asthma by inhibiting M2 macrophage polarization via disruption of the STAT6/IRF4 signaling pathway, supporting its potential as a therapeutic agent derived from traditional medicine.

Indexed as

Anti-Asthmatic AgentsAsthmaCoumaric AcidsInterferon Regulatory FactorsMacrophagesSTAT6 Transcription FactorAnimalsFemaleInterferon Regulatory Factor-4Interleukin-4LungMiceMice, Inbred BALB CPyroglyphidaeRAW 264.7 CellsSignal TransductionAnti-Asthmatic AgentsCoumaric AcidsInterferon Regulatory Factor-4Interferon Regulatory FactorsInterleukin-4Stat6 protein, mouseSTAT6 Transcription FactorAllergic asthmaEthyl ferulateIRF4M2 polarizationSTAT6

Identifiers

PMID42371045

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.