Evidence map›Paper›PMID 42371097›Full record

SynthesisJournal of gastroenterology2026

Risk of lymph-node metastasis in early onset T1 colorectal cancer: a systematic review and meta-analysis.

Hiromu Fukuda, Yoshito Hayashi, Shinji Yoneda, Yujiro Adachi, Ayaka Tajiri, Eiji Kimura, Ryotaro Uema, Takeo Yoshihara, Yoshiki Tsujii, Takahiro Kodama and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hiromu FukudaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Yoshito HayashiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan. y.hayashi@gh.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0003-4168-3322
Shinji YonedaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Yujiro AdachiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Ayaka TajiriDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Eiji KimuraDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Ryotaro UemaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Takeo YoshiharaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Yoshiki TsujiiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Takahiro KodamaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.
Tetsuo TakeharaDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Yamadaoka, 2-2, Suita, Osaka, 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the increasing incidence of early onset T1 colorectal cancer (T1 CRC), its features remain poorly understood. We examined whether early onset T1 CRC is associated with a higher rate of lymph-node metastasis (LNM).

methodsWe included studies reporting age-specific LNM rates for patients aged < 50 and ≥ 50 years. Sensitivity analyses were performed to assess the impact of overlapping and selected subset datasets. Subgroup analyses were conducted to evaluate the association between clinicopathological variables and age. The risk of bias was assessed using the Risk of Bias In Non-randomized Studies of Interventions Version 2.

resultsOf the 1214 records identified, 10 studies comprising 11 databases were included. After excluding overlapping and selected subset data, six databases from five studies with 29,132 patients were analyzed. Of these, 2759 (9.4%) were aged < 50 years at diagnosis, and the pooled LNM rates were 19.2% (95% confidence interval [CI], 17.8-20.6) in early onset and 11.1% (95% CI 10.7-11.5) in late-onset T1 CRC, representing an absolute difference of approximately 8%. Early onset T1 CRC was associated with higher odds of LNM than late-onset disease (OR: 1.94; 95% CI 1.75-2.15; I

conclusionsThis meta-analysis demonstrated that early onset T1 CRC is associated with higher odds of LNM compared with late-onset T1 CRC in surgically treated patients.

Indexed as

Colorectal NeoplasmsLymphatic MetastasisAge FactorsAge of OnsetHumansMiddle AgedNeoplasm StagingRisk FactorsColorectal cancerEarly onsetLymph-node metastasisT1

Identifiers

PMID42371097
PMCPMC13407934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.