Evidence map›Paper›PMID 42371130›Full record

Trial reportEuropean journal of nutrition2026

Patatin-like phosphatase domain-containing 3 genotype and quality of dietary fat modify the liver adiposity in men.

Milla-M Tauriainen, Maria A Lankinen, Juhana M Hakumäki, Olli M Lahtinen, Minna Husso, Jyrki J Ågren, Markku Laakso, Ursula S Schwab

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milla-M TauriainenUnit of Endoscopy, Department of Medicine, Kuopio University Hospital, North Savo Wellbeing County, Finland. milla-maria.tauriainen@pshyvinvointialue.fi.
Maria A LankinenSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Juhana M HakumäkiDiagnostic Imaging Centre, Department of Clinical Radiology, Kuopio University Hospital, North Savo Wellbeing County, Finland.
Olli M LahtinenDiagnostic Imaging Centre, Department of Clinical Radiology, Kuopio University Hospital, North Savo Wellbeing County, Finland.
Minna HussoDiagnostic Imaging Centre, Department of Clinical Radiology, Kuopio University Hospital, North Savo Wellbeing County, Finland.
Jyrki J ÅgrenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Ursula S SchwabSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatatin-like phosphatase domain-containing 3 (PNPLA3) gene and dietary fat are important factors for metabolic dysfunction-associated steatotic liver disease (MASLD).

objectiveWe studied the impact of dietary fat quality modification on liver adiposity in men homozygotes for PNPLA3 (GG, carriers of the risk allele and CC, non-carriers).

methodsNinety-eight men (age: 67.8 ± 4.2 years, body mass index: 27.2 ± 2.5 kg/m

resultsMRI-based liver fat proportion decreased in the RD arm (CC: from 3.8 ± 3.2 to 3.2 ± 3.3%, GG: from 3.9 ± 3.3 to 3.5 ± 3.1%, p time = 0.032) and increased in the AD arm (CC: from 4.1 ± 3.6 to 4.8 ± 3.9%, GG: from 4.7 ± 3.7 to 6.7 ± 5.3%, p time = 0.015). MRS-quantified liver saturated fat content increased in the AD arm in both genotypes of PNPLA3 (p time = 0.010). Liver triglyceride concentration did not change in either arm with the CC genotype but increased in the AD arm with the GG genotype (for time and genotype interaction p = 0.027).

conclusionDiet based on fat quality recommendations could be beneficial for liver health in both PNPLA3 genotypes CC and GG. The average diet seems to be especially harmful for liver health in carriers of the PNPLA3 risk genotype (GG).

Indexed as

AdiposityDietary FatsLipaseLiverMembrane ProteinsAcyltransferasesAgedFinlandGenotypeHumansMaleMiddle AgedPhospholipases A2, Calcium-IndependentAcyltransferasesDietary FatsLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanDiet fat qualityLiver fat contentLiver magnetic resonance imagingLiver magnetic resonance spectroscopyLiver steatosisMetabolic dysfunction-associated steatotic liver disease (MASLD)Patatin-like phosphatase domain-containing 3 gene

Identifiers

PMID42371130
PMCPMC13314847

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.