Evidence map›Paper›PMID 42371383›Full record

ArticleBiological trace element research2026

Prenatal Chromium Exposure and Gestational Diabetes Mellitus: Integrating Genetic and Epigenetic Regulation of LPCAT1 from a Phospholipid Remodeling Perspective.

Yuxin Tian, Lu Yao, Jiaqi Zhang, Meng Zhou, Yue Dou, Bole Zhang, Yulin Li, Yongliang Feng, Yawei Zhang, Suping Wang and 1 more

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Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yuxin TianDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Lu YaoDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Jiaqi ZhangDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Meng ZhouDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Yue DouDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Bole ZhangDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Yulin LiDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Yongliang FengDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Yawei ZhangNational Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Suping WangDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.
Weiwei WuDepartment of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China. weiwei.wu@sxmu.edu.cn.ORCID http://orcid.org/0000-0003-0756-9331

Funding

The National Natural Science Foundation [82373677]the Research Project Supported by Shanxi Scholarship Council of China [2023-099]
6 · The paper itself

Abstract

The trace element chromium (Cr) has been implicated in the risk of gestational diabetes mellitus (GDM), the underlying mechanisms remain unclear. Phospholipid remodeling is known to contribute to insulin regulation and may serve as a potential intermediate link between Cr exposure and GDM risk. Lysophosphatidylcholine acyltransferase 1 (LPCAT1), as an important regulatory factor in phospholipid remodeling, may play a certain role in this process. For the first time, this study investigates the relationship between Cr exposure and GDM risk from the perspective of phospholipid remodeling, while integrating the genetic predisposition and epigenetic regulation of the LPCAT1 gene. A cohort comprising 107 pregnant women diagnosed with GDM and 107 matched controls without GDM was recruited. Blood samples were collected prior to delivery to perform LPCAT1 genotyping, assess DNA methylation patterns, and quantify Cr concentrations. Elevated Cr levels in maternal blood were significantly correlated with an increased risk of GDM. Furthermore, a multiplicative interaction was observed between Cr exposure and four single nucleotide polymorphisms (SNPs) within the LPCAT1 gene. Three Cr-associated DNA methylation CpG sites were identified in GDM patients. Methylation quantitative trait locus (mQTLs) analysis revealed that three SNPs (rs4371798, rs56358072, rs6554859) were significantly associated with methylation at a specific CpG site (cg22185977) within LPCAT1. These findings suggest that genetic polymorphisms in LPCAT1 may modulate individual susceptibility to Cr exposure and consequent GDM risk by influencing the methylation status of the LPCAT1 gene. This study provides novel etiological insights into the role of Cr in inducing GDM through mechanisms involving phospholipid remodeling.

Indexed as

1-Acylglycerophosphocholine O-AcyltransferaseChromiumDiabetes, GestationalEpigenesis, GeneticPhospholipidsAdultDNA MethylationFemaleHumansPolymorphism, Single NucleotidePregnancy1-Acylglycerophosphocholine O-AcyltransferaseChromiumLpcat1 protein, humanPhospholipidsChromiumGestational diabetes mellitusLPCAT1mQTLs

Identifiers

PMID42371383

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.