ArticleDiabetes care2026
Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.
Article in Diabetes care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveWe examined associations of polygenic scores (PS) for macronutrient intake with food intake and cardiometabolic outcomes during childhood and adolescence and evaluated gene enrichment in hypothalamic cell types. RESEARCH DESIGN AND
methodsWe derived carbohydrate, fat, and protein intake PS from an adult genome-wide association study among 516 non-Hispanic White children from the Project Viva cohort. We estimated dietary intake and calculated BMI z scores from measured height and weight at ages ∼3, 8, 13, and 18 years. Waist circumference, truncal fat, fasting glucose, insulin, glycated hemoglobin, and blood lipids were measured at 18 years. We estimated associations of PS with sugar-sweetened beverages (SSB), fast food, and BMI z score using generalized estimating equations (longitudinal) and using regression models for cardiometabolic and secondary dietary outcomes (cross-sectional). We evaluated enrichment of macronutrient intake genetic signals in hypothalamic cell types in the Human HYPOMAP data set.
resultsA 1-SD increase in carbohydrate PS was associated with higher odds of consuming two or more servings per week of SSB (odds ratio [OR] 1.20; 95% CI 1.07, 1.33) and one or more times per week of fast food (OR 1.11; 95% CI 1.004, 1.23) from ages 3 to 18 years. Higher-protein PS was associated with lower odds of consuming SSB (OR 0.84; 95% CI 0.75, 0.93). We did not observe consistent associations between macronutrient intake PS and cardiometabolic outcomes. We observed hypothalamic regional and neurotransmitter-specific patterns of gene enrichment for carbohydrate or protein intake.
conclusionsGenetic susceptibility for carbohydrate intake is associated with SSB and fast-food consumption in youth. Underlying pathways relating to hypothalamic nutrient-specific appetite signaling may be involved.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.