ReviewDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2026
Screening for Barrett's esophagus and esophageal adenocarcinoma: recent advances and next steps.
Review in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The incidence of esophageal adenocarcinoma (EAC) has continued to increase, with a poor 5-year survival rate of ~20%. Barrett's esophagus is the only recognized precursor to EAC, so public health strategies focus on identifying and screening high-risk populations. Currently, the standard screening method is sedated esophagogastroduodenoscopy. However, this approach has challenges, including its invasive nature, need for sedation, higher cost, procedure-related risks, sampling error, and poor suitability for population-wide screening. As a result, alternative screening techniques such as transnasal endoscopy and less invasive options including non-endoscopic cell collection devices with biomarker assays have been explored. In this review, we summarize current approaches for identifying at-risk populations and screening methods and provide insights into technologies that could complement screening strategies in the future.
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