Evidence map›Paper›PMID 42372663›Full record

ArticleMolecular pharmacology2026

Effects of ivermectin on the activation and desensitization of the human GABA

Spencer R Pierce, Allison L Germann, Ka Tak Tsoi, Gustav Akk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Spencer R PierceDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Allison L GermannDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Ka Tak TsoiDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Gustav AkkDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri. Electronic address: akk@wustl.edu.

Funding

GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8M
NIGMS NIH HHS R35 GM140947NIH HHS R35GM140947
6 · The paper itself

Abstract

Ivermectin (IVM) is a widely used antiparasitic drug that acts through allosteric activation and potentiation of the glutamate-gated chloride channel present in neurons and muscle cells of helminths and insects. In mammals, IVM activates several members of the Cys-loop ion channel family, including the GABA

Indexed as

IvermectinReceptors, GABA-AAnimalsAntiparasitic AgentsFemalegamma-Aminobutyric AcidHumansOocytesXenopus laevisAntiparasitic Agentsgamma-Aminobutyric AcidIvermectinReceptors, GABA-AActivationAnestheticsDesensitizationGABA(A) receptorIvermectin

Identifiers

PMID42372663
PMCPMC13494235

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.