Evidence map›Paper›PMID 42373232›Full record

ArticleCancer genomics & proteomics

Germline Variation in Notch Pathway and Survival After Androgen Deprivation Therapy in Prostate Cancer: Implicating

Wen-Hua Chung, Chi-Fen Chang, Chao-Yuan Huang, Chia-Cheng Yu, Victor C Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

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Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wen-Hua Chung *Department of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Chi-Fen Chang *Department of Anatomy, School of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.
Chia-Cheng YuDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.
Victor C LinDepartment of Urology, E-Da Hospital, Kaohsiung, Taiwan, R.O.C.
Te-Ling LuDepartment of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Shu-Pin HuangGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.; shpihu@kmu.edu.tw bao@mail.cmu.edu.tw.
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.; shpihu@kmu.edu.tw bao@mail.cmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimNotch signaling exerts context-dependent effects in cancer; however, the prognostic relevance of inherited variation in Notch-related genes in prostate cancer remains unclear. We investigated whether germline single-nucleotide polymorphisms (SNPs) in Notch pathway genes are associated with clinical outcomes in men receiving androgen deprivation therapy (ADT). PATIENTS AND

methodsWe genotyped 222 SNPs across 24 Notch pathway-related genes in 630 patients with advanced prostate cancer. Associations with cancer-specific survival (CSS) and overall survival (OS) were assessed using Cox proportional hazards models. Integrative bioinformatics analyses, including pooled transcriptomic dataset analysis, expression quantitative trait locus analysis, and pathway enrichment, were performed to assess functional relevance.

resultsMultiple SNPs were significantly associated with CSS and OS, with Yes1-associated transcriptional regulator (

conclusionGermline variation in the Notch-YAP axis, notably

Indexed as

Adaptor Proteins, Signal TransducingAndrogen AntagonistsFocal AdhesionsGerm-Line MutationPolymorphism, Single NucleotideProstatic NeoplasmsReceptors, NotchTranscription FactorsAgedGene Expression Regulation, NeoplasticHumansMalePrognosisSignal TransductionYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAndrogen AntagonistsReceptors, NotchTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsandrogen deprivation therapyNotch signaling pathwayprognostic biomarkerProstate cancerYAP1

Identifiers

PMID42373232
PMCPMC13321707

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.